Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.61 |
| ▸ | MTOR | P42345 | 1/20 | 0.61 |
| ▸ | ADK | P55263 | 1/20 | 0.61 |
| ▸ | VCP | P55072 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 4/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.42 |
| ▸ | TOP1 | P11387 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2198284 | 0.85 | NISCH (0.67) | NISCHMTORADKVCPKDM4E | |
| SCHEMBL1288737 | 0.80 | NISCH (0.53) | NISCHMTORADKVCPKDM4E | |
| SCHEMBL6483506 | 0.79 | NISCH (0.67) | NISCHMTORADKVCPKDM4E | |
| SCHEMBL471923 | 0.78 | NISCH (0.70) | NISCHMTORADKVCPKDM4E | |
| SCHEMBL5148367 | 0.77 | NISCH (0.91) | NISCHMTORADKVCPKDM4E | |
| 2-Phenylimidazole SCHEMBL9719773 | 0.77 | NISCH (1.00) | NISCHMTORADKVCPKDM4E | |
| 2-Phenylimidazole SCHEMBL8901 | 0.77 | NISCH (1.00) | NISCHMTORADKVCPKDM4E | |
| SCHEMBL3644191 | 0.76 | NISCH (0.74) | NISCHMTORADKVCPKDM4E | |
| SCHEMBL28450350 | 0.76 | NISCH (0.57) | NISCHMTORADKVCPKDM4E | |
| SCHEMBL7060159 | 0.76 | NISCH (0.49) | NISCHMTORADKVCPKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0857171-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-08-12 | — | — | EP | disclosed |
| WO-1997015555-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-05-01 | — | — | WO | disclosed |