SCHEMBL8537535

SCHEMBL8537535

CCC[SiH]1CCC(c2ccc(-c3ccccc3OC(F)(F)F)c(F)c2)CC1

nearest known ligand 0.38

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
S1PR1 P21453 1/20 0.38
ALOX5AP P20292 1/20 0.37
FEN1 P39748 1/20 0.37
PDK2 Q15119 2/20 0.33
SCN9A Q15858 8/20 0.33
PLAT P00750 1/20 0.32
FFAR4 Q5NUL3 1/20 0.32
KCNN4 O15554 1/20 0.32
RORC P51449 2/20 0.32
TRPA1 O75762 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8537539 1.00 S1PR1 (0.38) S1PR1ALOX5APFEN1PDK2SCN9A
SCHEMBL8538287 0.86 FFAR4 (0.38) ALOX5APFEN1FFAR4
SCHEMBL8538286 0.86 FFAR4 (0.38) ALOX5APFEN1FFAR4
SCHEMBL7759077 0.84 CTSK (0.36) S1PR1ALOX5APFEN1
SCHEMBL7753084 0.82 GRM2 (0.40) ALOX5APFEN1FFAR4
SCHEMBL7753078 0.82 GRM2 (0.40) ALOX5APFEN1FFAR4
SCHEMBL8771254 0.79 EPHX2 (0.34)
SCHEMBL8771265 0.79 EPHX2 (0.34)
SCHEMBL8771246 0.79 EPHX2 (0.34)
SCHEMBL8771259 0.79 EPHX2 (0.34)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5762826-A Liquid crystal composition and a liquid crystal display element which contains it SHIN-ETSU CHEMICAL CO., LTD. (JP) 1998-06-09 US disclosed