SCHEMBL8537985

SCHEMBL8537985

c1ccc(P(Cc2ccccc2-c2c(CP(c3ccccc3)c3ccccc3)ccc3ccccc23)c2ccccc2)cc1

nearest known ligand 0.37

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
DNMT1 P26358 1/20 0.37
ALDH1A1 P00352 2/20 0.36
MAPT P10636 2/20 0.36
MEN1 O00255 1/20 0.36
HPGD P15428 1/20 0.36
KMT2A Q03164 1/20 0.36
WDR5 P61964 1/20 0.34
TDP1 Q9NUW8 2/20 0.33
CYP2A6 P11509 1/20 0.33
TSHR P16473 1/20 0.33
HSD17B10 Q99714 1/20 0.33
SOS1 Q07889 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
HPRT1 P00492 1/20 0.31
CA12 O43570 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5828913 0.91 DNMT1 (0.37) DNMT1ALDH1A1MAPTMEN1HPGD
SCHEMBL3955072 0.89 ALDH1A1 (0.39) DNMT1ALDH1A1MAPTWDR5TDP1
SCHEMBL29447338 0.89 ALDH1A1 (0.39) DNMT1ALDH1A1MAPTWDR5TDP1
SCHEMBL29695262 0.87 ALDH1A1 (0.38) DNMT1ALDH1A1MAPTWDR5TDP1
Potassium SCHEMBL29695394 0.85 WDR5 (0.37) DNMT1ALDH1A1MAPTWDR5TDP1
SCHEMBL8624095 0.83 MCL1 (0.35) DNMT1ALDH1A1MAPTMEN1HPGD
SCHEMBL21530764 0.81 PDCD1 (0.32) TDP1
SCHEMBL9861267 0.80 HPGD (0.33) DNMT1ALDH1A1MAPTMEN1HPGD
SCHEMBL10409108 0.80 CYP1A2 (0.31) DNMT1HPGDHSD17B10CYP1A2CYP2C9
SCHEMBL8056031 0.80 CES1 (0.36) ALDH1A1MAPTMEN1KMT2AWDR5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0446301-B1 PREPARATION OF BIARYL COMPOUNDS EASTMAN CHEM CO (US) 1994-11-23 EP claimed
US-5061669-A Catalyst comprising anhydrous nickel compound, bidentate phosphorus-containing ligand, reducing metal EASTMAN KODAK COMPANY (US) 1991-10-29 US claimed
EP-0446301-A1 PREPARATION OF BIARYL COMPOUNDS. EASTMAN KODAK CO (US) 1991-09-18 EP claimed
EP-0376856-A1 Preparation of biaryl compounds EASTMAN KODAK COMPANY (US) 1990-07-04 EP claimed
WO-1990006295-A1 PREPARATION OF BIARYL COMPOUNDS EASTMAN KODAK COMPANY (US) 1990-06-14 WO claimed
US-4916227-A From aromatic halide using coordinating catalyst containing nickel, phosphorus containing ligand, and reducing metal EASTMAN KODAK COMPANY (US) 1990-04-10 US claimed
EP-0571819-B1 Sulfonated 2,2'-bis(diphenylphosphinomethyl)-1,1'-binaphthalenes, process for their preparation and their use in a process for the hydroformylation of olefinic unsaturated compounds CELANESE GMBH (DE) 1998-11-11 EP disclosed
EP-0446301-B1 PREPARATION OF BIARYL COMPOUNDS EASTMAN CHEM CO (US) 1994-11-23 EP disclosed
EP-0386105-B1 A PROCESS FOR THE PREPARATION OF BIDENTATE LIGANDS EASTMAN KODAK CO (US) 1993-12-29 EP disclosed
EP-0571819-A1 Sulfonated 2,2'-bis(diphenylphosphinomethyl)-1,1'binaphthalenes, process for their preparation and their use in a process for the hydroformylation of olefinic unsaturated compounds HOECHST AKTIENGESELLSCHAFT (DE) 1993-12-01 EP disclosed
EP-0326286-B1 PREPARATION OF BIDENTATE LIGANDS EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1993-02-10 EP disclosed
EP-0419485-B1 PREPARATION OF BIDENTATE LIGANDS EASTMAN KODAK COMPANY (US) 1993-01-20 EP disclosed
CN-1019111-B CHELATED LIGANDS USED AS CATALYST FOR LOW PRESSURE CARBOXYLATION AND ITS USE EASTMAN KODAK CO (US) 1992-11-18 CN disclosed
EP-0326286-A1 Preparation of bidentate ligands EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1989-08-02 EP disclosed
WO-1989006653-A1 PREPARATION OF BIDENTATE LIGANDS EASTMAN KODAK COMPANY (US) 1989-07-27 WO disclosed
EP-0311619-A1 CHELATE LIGANDS FOR LOW PRESSURE HYDROFORMYLATION CATALYST AND PROCESS EMPLOYING SAME. EASTMAN KODAK CO (US) 1989-04-19 EP disclosed
CN-1032002-A The chelating ligand and the using method thereof that are used for the low pressure carbonylation catalyst EASTMAN KODAK CO (US) 1989-03-29 CN disclosed
EP-0279018-A1 Chelate ligands for low pressure hydroformylation catalyst and process employing same EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1988-08-24 EP disclosed
US-4760194-A Hydroformylation, reacting olefin with carbon monoxide and hydrogen in presence of rhodium complex catalyst EASTMAN KODAK COMPANY (US) 1988-07-26 US disclosed
WO-1987007600-A2 CHELATE LIGANDS FOR LOW PRESSURE HYDROFORMYLATION CATALYST AND PROCESS EMPLOYING SAME EASTMAN KODAK COMPANY (US) 1987-12-17 WO disclosed