Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.47 |
| ▸ | ALPL | P05186 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12892190 | 0.83 | NT5E (0.57) | SMN1; SMN2ALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL15326541 | 0.83 | MEN1 (0.55) | SMN1; SMN2ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL8773951 | 0.82 | ALPL (0.43) | ALDH1A1ALPLMEN1KMT2AF2 | |
| SCHEMBL10788892 | 0.82 | LMNA (0.51) | SMN1; SMN2KDM4EPTGS1MAPTMEN1 | |
| SCHEMBL151398 | 0.82 | NPC1 (0.50) | SMN1; SMN2MEN1KMT2AF2BTK | |
| SCHEMBL10790921 | 0.81 | KCNK3 (0.47) | ALPLMEN1KMT2AL3MBTL1 | |
| SCHEMBL4552794 | 0.81 | ALPL (0.50) | ALDH1A1KDM4EALPLMEN1KMT2A | |
| SCHEMBL13876946 | 0.80 | ALPL (0.40) | SMN1; SMN2KDM4EALPLMAPTMEN1 | |
| SCHEMBL12892192 | 0.80 | KDM4E (0.46) | SMN1; SMN2HSD17B10KDM4EALPLKMT2A | |
| SCHEMBL8533619 | 0.79 | KMT2A (0.60) | SMN1; SMN2NPSR1ALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0135032-B1 | CARBAMATES AND OXALYL AMIDES OF AMINO-N-(1H-TETRAZOL-5-YL) BENZAMIDES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-09-30 | — | — | EP | claimed |
| EP-0135032-A1 | Carbamates and oxalyl amides of amino-N-(1H-tetrazol-5-yl) benzamides | MERRELL DOW PHARMACEUTICALS INC. (US) | 1985-03-27 | — | — | EP | claimed |
| US-5763437-A | Benzodiazepine derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-06-09 | — | — | US | disclosed |
| EP-0804425-A2 | BENZODIAZEPINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996004254-A2 | BENZODIAZEPINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-02-15 | — | — | WO | disclosed |