SCHEMBL8538573

SCHEMBL8538573

N=C(N)Nc1cccc(C(=O)NCC(=Cc2ccccc2)C(=O)O)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 1/20 0.41
LMNA P02545 5/20 0.41
MAPT P10636 4/20 0.41
HTT P42858 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
SENP2 Q9HC62 1/20 0.41
SENP1 Q9P0U3 1/20 0.41
BCHE P06276 1/20 0.40
PKM P14618 1/20 0.40
KCNK3 O14649 2/20 0.40
KCNK9 Q9NPC2 2/20 0.40
PAX8 Q06710 1/20 0.39
SIRT2 Q8IXJ6 1/20 0.39
MEN1 O00255 2/20 0.39
ALDH1A1 P00352 2/20 0.39
KMT2A Q03164 2/20 0.39
MAPK1 P28482 2/20 0.39
KDM4E B2RXH2 1/20 0.39
POLB P06746 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6366986 0.81 PLA2G10 (0.47) LMNAMAPTHTTSMN1; SMN2L3MBTL1
Hydrochloric Acid SCHEMBL6773326 0.80 PLA2G10 (0.46) LMNAMAPTHTTSMN1; SMN2L3MBTL1
Hydrochloric Acid SCHEMBL6368863 0.80 PLA2G10 (0.46) LMNAMAPTHTTSMN1; SMN2L3MBTL1
SCHEMBL7343748 0.80 MEN1 (0.46) LMNAMAPTHTTSMN1; SMN2L3MBTL1
SCHEMBL8539549 0.80 KDM4E (0.47) LMNAMAPTHTTSMN1; SMN2PKM
SCHEMBL8520753 0.80 KMT2A (0.48) EPHX2SMN1; SMN2KCNK3KCNK9SIRT2
SCHEMBL7372871 0.79 PLK4 (0.50) SMN1; SMN2KCNK3KCNK9MEN1ALDH1A1
SCHEMBL7343738 0.79 PLK4 (0.47) LMNAMAPTHTTSMN1; SMN2L3MBTL1
SCHEMBL26033646 0.78 PLK4 (0.49) SMN1; SMN2BCHEKCNK3KCNK9MEN1
SCHEMBL8541181 0.76 SIRT2 (0.52) LMNAMAPTHTTPKMKCNK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5852210-A Cinnamic acid derivatives G. D. SEARLE & CO. (US) 1998-12-22 US claimed