Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.45 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.45 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | CHUK | O15111 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | PAK4 | O96013 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8520762 | 0.85 | KMT2A (0.44) | KMT2AMEN1NPC1POLBITGB3 | |
| SCHEMBL8520922 | 0.84 | FFAR1 (0.46) | KMT2AMEN1NPC1ITGB3ITGA2B | |
| SCHEMBL7572346 | 0.84 | ITGB3 (0.50) | KMT2AMEN1NPC1POLBITGB3 | |
| SCHEMBL7498232 | 0.83 | NR1H4 (0.41) | KMT2AMEN1NPC1POLBITGB3 | |
| SCHEMBL7506955 | 0.80 | KMT2A (0.50) | KMT2AMEN1NPC1POLBKCNK3 | |
| SCHEMBL7497380 | 0.80 | KMT2A (0.50) | KMT2AMEN1NPC1POLBKCNK3 | |
| SCHEMBL8538573 | 0.80 | EPHX2 (0.41) | KMT2AMEN1POLBKCNK3KCNK9 | |
| SCHEMBL8520757 | 0.79 | KMT2A (0.51) | KMT2AMEN1NPC1POLBITGB3 | |
| SCHEMBL7506884 | 0.78 | ITGB3 (0.66) | KMT2ANPC1POLBITGB3ITGA2B | |
| SCHEMBL7508818 | 0.78 | ITGB3 (0.66) | KMT2ANPC1POLBITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0894084-A1 | CINNAMIC ACID DERIVATIVES AND THEIR USE AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1999-02-03 | — | — | EP | disclosed |
| WO-1997036860-A1 | CINNAMIC ACID DERIVATIVES AND THEIR USE AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | disclosed |