Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 5/20 | 0.79 |
| ▸ | NAMPT | P43490 | 6/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8538689 | 0.95 | TBXAS1 (0.84) | TBXAS1NAMPTMEN1KMT2A | |
| SCHEMBL8539741 | 0.91 | TBXAS1 (0.91) | TBXAS1PTGDR2MEN1KMT2A | |
| SCHEMBL8539221 | 0.88 | TBXAS1 (1.00) | TBXAS1PTGDR2MEN1KMT2A | |
| SCHEMBL8539906 | 0.84 | TBXAS1 (0.65) | TBXAS1PTGDR2 | |
| SCHEMBL8538702 | 0.82 | TBXAS1 (0.64) | TBXAS1 | |
| SCHEMBL8543940 | 0.82 | TBXAS1 (0.65) | TBXAS1PTGDR2MEN1KMT2A | |
| SCHEMBL8539323 | 0.81 | TBXAS1 (0.61) | TBXAS1PTGDR2 | |
| SCHEMBL8581509 | 0.81 | TBXAS1 (0.61) | TBXAS1PTGDR2 | |
| SCHEMBL8637450 | 0.79 | TBXAS1 (0.59) | TBXAS1PTGDR2MEN1KMT2A | |
| SCHEMBL8539463 | 0.78 | TBXAS1 (0.83) | TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0715627-B1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | PFIZER LTD (GB) | 1998-09-09 | — | — | EP | claimed |
| US-5744488-A | 1-CARBOXYALKYL-3-ALKYL OR PHENYL-5-ORGANOSULFONAMIDE OR -AMIDE INDOLES; ATHERSCLEROSIS; ANGINA; PREVENTING ANGIOPLASTY OCCULSION; THROMBOXANE SYNTHETASE INHIBITORS | PFIZER INC. (US) | 1998-04-28 | — | — | US | claimed |
| WO-1995006046-A1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | PFIZER LIMITED (GB) | 1995-03-02 | — | — | WO | claimed |