Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 13/20 | 0.57 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.53 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8539586 | 0.95 | TBXAS1 (0.63) | TBXAS1TBXA2RPTGDR2 | |
| SCHEMBL8541102 | 0.89 | TBXAS1 (0.48) | TBXAS1TBXA2RPTGDR2 | |
| SCHEMBL8539547 | 0.87 | TBXAS1 (0.53) | TBXAS1TBXA2RPTGDR2 | |
| SCHEMBL8539741 | 0.78 | TBXAS1 (0.91) | TBXAS1TBXA2RPTGDR2 | |
| SCHEMBL8539221 | 0.73 | TBXAS1 (1.00) | TBXAS1TBXA2RPTGDR2 | |
| SCHEMBL8537998 | 0.70 | TBXAS1 (0.73) | TBXAS1TBXA2RPTGDR2 | |
| SCHEMBL8539267 | 0.70 | TBXAS1 (0.79) | TBXAS1PTGDR2 | |
| SCHEMBL9195934 | 0.70 | TBXAS1 (0.69) | TBXAS1TBXA2R | |
| SCHEMBL10447700 | 0.69 | TBXAS1 (0.55) | TBXAS1TBXA2R | |
| SCHEMBL10447701 | 0.69 | TBXAS1 (0.55) | TBXAS1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0715627-B1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | PFIZER LTD (GB) | 1998-09-09 | — | — | EP | claimed |
| US-5744488-A | 1-CARBOXYALKYL-3-ALKYL OR PHENYL-5-ORGANOSULFONAMIDE OR -AMIDE INDOLES; ATHERSCLEROSIS; ANGINA; PREVENTING ANGIOPLASTY OCCULSION; THROMBOXANE SYNTHETASE INHIBITORS | PFIZER INC. (US) | 1998-04-28 | — | — | US | claimed |
| EP-0715627-A1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | Pfizer Limited (GB) | 1996-06-12 | — | — | EP | claimed |
| WO-1995006046-A1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | PFIZER LIMITED (GB) | 1995-03-02 | — | — | WO | claimed |