Flurochloridone

Flurochloridone

SCHEMBL8539437

O=C1C(Cl)C(CCl)CN1c1cccc(C(F)(F)F)c1.O=C1C(Cl)C(CCl)CN1c1cccc(C(F)(F)F)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 3/20 0.43
DRD3 P35462 3/20 0.43
ALOX5 P09917 2/20 0.42
KCNH2 Q12809 1/20 0.41
PTGS1 P23219 1/20 0.41
PTGS2 P35354 1/20 0.41
NOTUM Q6P988 1/20 0.41
HTR7 P34969 1/20 0.41
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
LMNA P02545 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
CA12 O43570 1/20 0.40
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
CA9 Q16790 1/20 0.40
KDM4E B2RXH2 1/20 0.40
ALDH1A1 P00352 1/20 0.40
MAPT P10636 1/20 0.40
GRM2 Q14416 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Flurochloridone SCHEMBL10985578 1.00 DRD2 (0.43) DRD2DRD3ALOX5KCNH2PTGS1
Flurochloridone SCHEMBL9668444 1.00 DRD2 (0.43) DRD2DRD3ALOX5KCNH2PTGS1
Flurochloridone SCHEMBL29471429 1.00 DRD2 (0.43) DRD2DRD3ALOX5KCNH2PTGS1
Flurochloridone SCHEMBL9668435 1.00 DRD2 (0.43) DRD2DRD3ALOX5KCNH2PTGS1
Flurochloridone SCHEMBL54056 1.00 DRD2 (0.43) DRD2DRD3ALOX5KCNH2PTGS1
SCHEMBL10971101 0.90 DRD2 (0.41) DRD2DRD3ALOX5KCNH2PTGS1
SCHEMBL10962520 0.90 DRD2 (0.43) DRD2DRD3ALOX5KCNH2PTGS1
SCHEMBL10966447 0.90 DRD2 (0.43) DRD2DRD3ALOX5KCNH2PTGS1
SCHEMBL10962036 0.90 DRD2 (0.43) DRD2DRD3ALOX5KCNH2PTGS1
SCHEMBL9681581 0.89 HTR7 (0.42) DRD2DRD3ALOX5KCNH2PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0574418-B1 ARYL SULPHONYL UREA COMPOUNDS, A METHOD OF PREPARING THEM, AND THEIR USE AS HERBICIDES AND GROWTH REGULATORS HOECHST SCHERING AGREVO GMBH (DE) 1998-11-11 EP disclosed
US-5463081-A Chemical intermediates HOECHST AKTIENGESELLSCHAFT (DE) 1995-10-31 US disclosed
EP-0574418-A1 ARYL SULPHONYL UREA COMPOUNDS, A METHOD OF PREPARING THEM, AND THEIR USE AS HERBICIDES AND GROWTH REGULATORS Hoechst Schering AgrEvo GmbH (DE) 1993-12-22 EP disclosed
EP-0548264-A1 HERBICIDAL SUBSTITUTED BICYCLIC TRIAZOLES. DU PONT (US) 1993-06-30 EP disclosed
WO-1992020684-A1 HERBICIDAL OXATRICYCLIC ETHERS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-11-26 WO disclosed
WO-1992013845-A1 ARYL SULPHONYL UREA COMPOUNDS, A METHOD OF PREPARING THEM, AND THEIR USE AS HERBICIDES AND GROWTH REGULATORS HOECHST AKTIENGESELLSCHAFT (DE) 1992-08-20 WO disclosed
WO-1992009587-A1 HERBICIDAL OXAZINE ETHERS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-06-11 WO disclosed
WO-1992004827-A1 HERBICIDAL SUBSTITUTED BICYCLIC TRIAZOLES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-04-02 WO disclosed