Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | G6PD | P11413 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MPI | P34949 | 1/20 | 0.42 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.42 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9644106 | 0.78 | NR3C1 (0.54) | ESR1LMNAESR2TSHRMEN1 | |
| SCHEMBL1766250 | 0.76 | ESR1 (0.43) | ESR1LMNAHSD17B10ESR2TSHR | |
| SCHEMBL3985314 | 0.76 | ESR1 (0.43) | ESR1LMNAHSD17B10ESR2TSHR | |
| SCHEMBL9644894 | 0.74 | SHBG (0.49) | ESR1ESR2SLC22A1ALDH1A1NR3C1 | |
| SCHEMBL19042784 | 0.74 | ESR1 (0.43) | ESR1LMNATSHRMAPTCYP1A2 | |
| SCHEMBL9019816 | 0.74 | ESR1 (0.43) | ESR1LMNATSHRMAPTCYP1A2 | |
| SCHEMBL19032703 | 0.74 | ESR1 (0.43) | ESR1LMNATSHRMAPTCYP1A2 | |
| SCHEMBL3451745 | 0.73 | ESR1 (0.58) | ESR1LMNAHSD17B10ESR2TSHR | |
| SCHEMBL9558275 | 0.73 | ESR1 (0.58) | ESR1LMNAHSD17B10ESR2TSHR | |
| SCHEMBL8536270 | 0.73 | SERPINA6 (0.57) | ESR1LMNAHSD17B10ESR2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843933-A | 11β-aryl-4-estrenes, process for their production as well as their use as pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-12-01 | — | — | US | disclosed |
| US-5728689-A | ANTIGESTAGENIC EFFECT | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-03-17 | — | — | US | disclosed |