Fluorodifen

Fluorodifen

SCHEMBL8539624

O=[N+]([O-])c1ccc(Oc2ccc(C(F)(F)F)cc2[N+](=O)[O-])cc1.O=[N+]([O-])c1ccc(Oc2ccc(C(F)(F)F)cc2[N+](=O)[O-])cc1

nearest known ligand 0.69

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSPB1 P04792 2/20 0.63
MAPT P10636 6/20 0.59
MEN1 O00255 3/20 0.59
KMT2A Q03164 3/20 0.59
ALDH1A1 P00352 3/20 0.59
HPGD P15428 3/20 0.58
LMNA P02545 2/20 0.58
SMN1; SMN2 Q16637 1/20 0.58
KDM4E B2RXH2 2/20 0.54
CYP2C9 P11712 1/20 0.54
MAPK1 P28482 1/20 0.54
PTPN1 P18031 1/20 0.53
POLB P06746 1/20 0.53
TDP1 Q9NUW8 2/20 0.52
TTR P02766 1/20 0.52
PPOX P50336 1/20 0.52
NPSR1 Q6W5P4 2/20 0.51
MASP2 O00187 1/20 0.51
F2 P00734 1/20 0.51
RAB9A P51151 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fluorodifen SCHEMBL39283 1.00 HSPB1 (0.63) HSPB1MAPTMEN1KMT2AALDH1A1
Fluorodifen SCHEMBL29419116 1.00 HSPB1 (0.63) HSPB1MAPTMEN1KMT2AALDH1A1
SCHEMBL31090851 0.93 LMNA (0.62) HSPB1MAPTMEN1KMT2AALDH1A1
SCHEMBL14677574 0.93 LMNA (0.62) HSPB1MAPTMEN1KMT2AALDH1A1
SCHEMBL11856448 0.91 HSPB1 (0.72) HSPB1MAPTMEN1KMT2AALDH1A1
SCHEMBL7200200 0.90 LMNA (0.60) HSPB1MAPTMEN1KMT2AALDH1A1
SCHEMBL27706701 0.89 HSPB1 (0.60) HSPB1MAPTMEN1KMT2AALDH1A1
SCHEMBL8684705 0.89 LMNA (0.58) HSPB1MAPTMEN1KMT2AALDH1A1
SCHEMBL8684713 0.87 LMNA (0.60) HSPB1MAPTMEN1KMT2AALDH1A1
SCHEMBL31090831 0.87 MAPT (0.60) MAPTMEN1KMT2AALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0574418-B1 ARYL SULPHONYL UREA COMPOUNDS, A METHOD OF PREPARING THEM, AND THEIR USE AS HERBICIDES AND GROWTH REGULATORS HOECHST SCHERING AGREVO GMBH (DE) 1998-11-11 EP disclosed
US-5688745-A Arylsulfonylureas and their use as herbicides and growth regulators HOECHST AKTIENGESELLSCHAFT (DE) 1997-11-18 US disclosed
US-5463081-A Chemical intermediates HOECHST AKTIENGESELLSCHAFT (DE) 1995-10-31 US disclosed