Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | KCNE1 | P15382 | 4/20 | 0.56 |
| ▸ | KCNQ1 | P51787 | 4/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.56 |
| ▸ | ABCB1 | P08183 | 12/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.47 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.47 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.47 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9472163 | 0.81 | KDM4E (0.57) | KDM4EKCNE1KCNQ1CYP3A4CYP1A2 | |
| SCHEMBL8537722 | 0.77 | ABCC9 (0.55) | ABCB1ABCC9 | |
| SCHEMBL4256349 | 0.77 | ABCC9 (0.53) | KDM4EKCNE1KCNQ1CYP3A4CYP1A2 | |
| SCHEMBL7869407 | 0.77 | ABCC9 (0.53) | KDM4EKCNE1KCNQ1CYP3A4CYP1A2 | |
| SCHEMBL8539686 | 0.77 | ABCC9 (0.55) | ABCB1ABCC9 | |
| SCHEMBL7359526 | 0.77 | ABCC9 (0.53) | KDM4EKCNE1KCNQ1CYP3A4CYP1A2 | |
| SCHEMBL5578941 | 0.77 | ABCC9 (0.53) | KDM4EKCNE1KCNQ1CYP3A4CYP1A2 | |
| SCHEMBL9876369 | 0.77 | KDM4E (0.56) | KDM4EKCNE1KCNQ1CYP3A4CYP1A2 | |
| SCHEMBL9876365 | 0.77 | KDM4E (0.56) | KDM4EKCNE1KCNQ1CYP3A4CYP1A2 | |
| SCHEMBL8589788 | 0.75 | KDM4E (0.47) | KDM4ECYP1A2CYP2D6CYP2C19ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0489327-B1 | Chroman derivatives | MERCK PATENT GMBH (DE) | 1998-05-27 | — | — | EP | claimed |
| US-5238937-A | PYRIDAZINY OR OXODIHYDROPYRIDAZINYL CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT (DE) | 1993-08-24 | — | — | US | claimed |
| EP-0489327-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1992-06-10 | — | — | EP | claimed |
| EP-0489327-B1 | Chroman derivatives | MERCK PATENT GMBH (DE) | 1998-05-27 | — | — | EP | disclosed |
| US-5238937-A | PYRIDAZINY OR OXODIHYDROPYRIDAZINYL CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT (DE) | 1993-08-24 | — | — | US | disclosed |
| EP-0489327-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1992-06-10 | — | — | EP | disclosed |