Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | HTR7 | P34969 | 2/20 | 0.48 |
| ▸ | HTR3A | P46098 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29022359 | 0.82 | RPS6KA5 (0.42) | POLBHTR7HTR3ASMN1; SMN2TDP1 | |
| SCHEMBL28554146 | 0.80 | GAA (0.50) | POLBRAB9ASMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL28469348 | 0.80 | POLB (0.46) | POLBHTR7RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL26297808 | 0.79 | POLB (0.49) | POLBHTR7HTR3ARAB9ASMN1; SMN2 | |
| SCHEMBL19329297 | 0.79 | POLB (0.49) | POLBHTR7HTR3ARAB9ASMN1; SMN2 | |
| SCHEMBL19100158 | 0.79 | RPS6KA5 (0.52) | POLBTDP1ALDH1A1MAPK1KDM4E | |
| SCHEMBL28180400 | 0.77 | CDC7 (0.58) | CDC7CDK2 | |
| SCHEMBL13335086 | 0.77 | POLB (0.46) | POLBHTR7HTR3ARAB9ASMN1; SMN2 | |
| SCHEMBL18585738 | 0.76 | CDC7 (0.60) | CDC7CDK2 | |
| SCHEMBL26297807 | 0.76 | HTR7 (0.48) | POLBHTR7HTR3ARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0580502-B1 | 3-(Hydroxybenzylidenyl)-indoline-2-ones and pharmaceutical compositions containing them | ADIR (FR) | 1998-09-02 | — | — | EP | disclosed |
| US-5382593-A | Antioxidants or anticoagulants | ADIR ET COMPAGNIE (FR) | 1995-01-17 | — | — | US | disclosed |
| EP-0580502-A1 | 3-(Hydroxybenzylidenyl)-indoline-2-ones and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-01-26 | — | — | EP | disclosed |