Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 2/20 | 0.55 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.45 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.45 |
| ▸ | C5 | P01031 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | RHEB | Q15382 | 5/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24076592 | 0.80 | GRIN1 (0.47) | GRIN1EIF4A3RHEBGRIN2DGRIN3B | |
| SCHEMBL8545425 | 0.77 | PTGS2 (0.47) | EIF4A3MEN1KMT2APTGS2ABCC4 | |
| SCHEMBL22529435 | 0.77 | GRIN1 (0.45) | GRIN1EIF4A3RHEBGRIN2DGRIN3B | |
| SCHEMBL20778457 | 0.76 | GRIN1 (0.51) | GRIN1EIF4A3MEN1KMT2ARHEB | |
| SCHEMBL8541911 | 0.74 | GRIN2D (0.40) | GRIN1EIF4A3MEN1KMT2APTGS2 | |
| SCHEMBL29531428 | 0.71 | GRIN1 (1.00) | GRIN1EIF4A3MEN1KMT2ARHEB | |
| SCHEMBL727389 | 0.71 | GRIN1 (1.00) | GRIN1EIF4A3MEN1KMT2ARHEB | |
| SCHEMBL22529402 | 0.70 | GRIN1 (0.72) | GRIN1EIF4A3MEN1KMT2ARHEB | |
| SCHEMBL20778459 | 0.70 | GRIN1 (0.42) | GRIN1EIF4A3RHEBALOX15 | |
| SCHEMBL24028983 | 0.70 | ALOX15 (0.62) | GRIN1EIF4A3MEN1KMT2ARHEB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0483881-B1 | 3-Amidoindolyl derivatives | MERRELL PHARMA INC (US) | 1998-01-21 | — | — | EP | disclosed |
| US-5703107-A | CENTRAL NERVOUS SYSTEM DISORDERS; ANALGESICS; ANTIEPILEPTIC AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1997-12-30 | — | — | US | disclosed |
| US-5675018-A | 3-amidoindolyl derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1997-10-07 | — | — | US | disclosed |
| US-5491153-A | 3-amidoindolyl derivative | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-02-13 | — | — | US | disclosed |
| EP-0526478-B1 | 3-INDOLYL THIOACETATE DERIVATIVES | MERRELL DOW PHARMA (US) | 1995-03-15 | — | — | EP | disclosed |
| US-5189054-A | 3-amidoindolyl derivatives and pharmaceutical compositions thereof | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-02-23 | — | — | US | disclosed |
| EP-0526478-A1 | 3-INDOLYL THIOACETATE DERIVATIVES. | MERRELL DOW PHARMA (US) | 1993-02-10 | — | — | EP | disclosed |
| EP-0483881-A1 | 3-Amidoindolyl derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1992-05-06 | — | — | EP | disclosed |
| WO-1991016307-A1 | 3-INDOLYL THIOACETATE DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-10-31 | — | — | WO | disclosed |
| US-5051442-A | 3-indolyl thioacetate derivatives and NMDA receptor antagonistic use thereof | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-09-24 | — | — | US | disclosed |