SCHEMBL8540400

SCHEMBL8540400

CCOC(=O)Nc1ccc(NC(=O)OCC)c2c1C(=O)c1cncnc1C2=O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.46
CYP2C9 P11712 2/20 0.46
CYP2C19 P33261 2/20 0.46
SMN1; SMN2 Q16637 1/20 0.45
TOP2A P11388 1/20 0.43
TOP2B Q02880 1/20 0.43
PTPN1 P18031 1/20 0.41
ALDH1A1 P00352 5/20 0.39
HPGD P15428 2/20 0.39
CDC25B P30305 1/20 0.39
KCNQ3 O43525 1/20 0.38
KCNQ2 O43526 1/20 0.38
ABCB11 O95342 1/20 0.38
ESR1 P03372 1/20 0.38
CYP3A4 P08684 1/20 0.38
HTR1A P08908 1/20 0.38
ADRA2A P08913 1/20 0.38
ADORA3 P0DMS8 1/20 0.38
CYP2D6 P10635 1/20 0.38
ALOX15 P16050 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8541126 0.81 TDP2 (0.56) CYP1A2CYP2C9CYP2C19SMN1; SMN2PTPN1
SCHEMBL8545860 0.81 ECE1 (0.51) CYP1A2CYP2C9CYP2C19SMN1; SMN2PTPN1
SCHEMBL23926998 0.72 ALDH1A1 (0.49) CYP1A2CYP2C9CYP2C19SMN1; SMN2ALDH1A1
SCHEMBL30258095 0.72 ALDH1A1 (0.49) CYP1A2CYP2C9CYP2C19SMN1; SMN2ALDH1A1
SCHEMBL7116909 0.71 PTPN1 (0.53) CYP1A2CYP2C9CYP2C19SMN1; SMN2PTPN1
SCHEMBL11569428 0.69 PTPN1 (0.51) CYP1A2CYP2C9CYP2C19SMN1; SMN2PTPN1
SCHEMBL6657424 0.67 ALDH1A1 (0.46) CYP1A2CYP2C9CYP2C19SMN1; SMN2ALDH1A1
SCHEMBL13564143 0.66 PTPN1 (0.47) CYP1A2CYP2C9CYP2C19SMN1; SMN2PTPN1
SCHEMBL22110710 0.65 KMT2A (0.49) CYP1A2CYP2C9CYP2C19SMN1; SMN2ALDH1A1
SCHEMBL23235636 0.65 CDC25B (0.72) CYP1A2CYP2C19TOP2ATOP2BALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0639183-B1 NITROGEN OXIDES OF AZA- AND DIAZA-ANTHRACENEDIONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS BOEHRINGER MANNHEIM ITALIA (IT) 1998-07-01 EP disclosed
EP-0503537-B1 6,9 Bis(substituted-amino)benzo-[g]isoquinoline-5,10-diones UNIV VERMONT (US) 1997-05-14 EP disclosed
EP-0574433-B1 6,9-BIS(AMINO SUBSTITUTED)BENZO g]PHTHALAZINE-5,10-DIONES AS ANTITUMOR AGENTS BOEHRINGER MANNHEIM ITALIA (IT) 1995-05-31 EP disclosed
EP-0639183-A1 NITROGEN OXIDES OF AZA- AND DIAZA-ANTHRACENEDIONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1995-02-22 EP disclosed
EP-0575526-A4 1994-03-30 EP disclosed
EP-0575526-A1 6,9 BIS(SUBSTITUTED-AMINO)BENZO g]ISOQUINOLINE-5,10-DIONES THE UNIVERSITY OF VERMONT (US) 1993-12-29 EP disclosed
WO-1992015300-A1 6,9 BIS(SUBSTITUTED-AMINO)BENZO[g]ISOQUINOLINE-5,10-DIONES THE UNIVERSITY OF VERMONT (US) 1992-09-17 WO disclosed
EP-0503537-A1 6,9 Bis(substituted-amino)benzo-[g]isoquinoline-5,10-diones THE UNIVERSITY OF VERMONT (US) 1992-09-16 EP disclosed