Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.56 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | SCD5 | Q86SK9 | 3/20 | 0.44 |
| ▸ | SCD | O00767 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8540457 | 1.00 | RIPK1 (0.56) | RIPK1ADAM17HSP90AA1HSP90AB1RAB9A | |
| SCHEMBL8546239 | 0.96 | RIPK1 (0.51) | RIPK1ADAM17HSP90AA1HSP90AB1RAB9A | |
| SCHEMBL8540511 | 0.96 | RIPK1 (0.51) | RIPK1ADAM17HSP90AA1HSP90AB1RAB9A | |
| SCHEMBL8540509 | 0.96 | RIPK1 (0.51) | RIPK1ADAM17HSP90AA1HSP90AB1RAB9A | |
| SCHEMBL8545905 | 0.95 | RIPK1 (0.50) | RIPK1ADAM17HSP90AA1HSP90AB1RAB9A | |
| SCHEMBL8539202 | 0.95 | RIPK1 (0.50) | RIPK1ADAM17HSP90AA1HSP90AB1RAB9A | |
| SCHEMBL6439008 | 0.83 | ALDH1A1 (0.53) | HSD17B10 | |
| SCHEMBL6435766 | 0.83 | ALDH1A1 (0.53) | HSD17B10 | |
| SCHEMBL6435771 | 0.83 | ALDH1A1 (0.53) | HSD17B10 | |
| SCHEMBL6436519 | 0.83 | ALDH1A1 (0.53) | HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705259-B1 | PHENYRROLE DERIVATIVES AND THEIR USE AS DOPAMINE D3 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1998-02-25 | — | — | EP | disclosed |
| EP-0705259-A1 | PHENYRROLE DERIVATIVES AND THEIR USE AS DOPAMINE D3 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-04-10 | — | — | EP | disclosed |
| WO-1995000508-A1 | PHENYRROLE DERIVATIVES AND THEIR USE AS DOPAMINE D3 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-01-05 | — | — | WO | disclosed |