Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 2/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | ADK | P55263 | 1/20 | 0.34 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.34 |
| ▸ | GRK2 | P25098 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8612212 | 0.90 | MC4R (0.37) | MC4RCASP6IDO1CSNK1A1TYRO3 | |
| SCHEMBL31429694 | 0.79 | IDO1 (0.51) | CASP6IDO1CSNK1A1TYRO3DYRK1B | |
| SCHEMBL6951802 | 0.78 | CSNK1A1 (0.50) | MC4RCASP6IDO1CSNK1A1TYRO3 | |
| SCHEMBL31429733 | 0.78 | IDO1 (0.58) | IDO1CSNK1A1TYRO3DYRK1BPIM1 | |
| SCHEMBL29084865 | 0.78 | IDO1 (0.58) | IDO1CSNK1A1TYRO3DYRK1BPIM1 | |
| SCHEMBL8542466 | 0.76 | ALDH1A1 (0.49) | IDO1CSNK1A1TYRO3DYRK1BNPC1 | |
| SCHEMBL3631532 | 0.74 | RAB9A (0.50) | CSNK1A1TYRO3DYRK1BNPC1RAB9A | |
| SCHEMBL8537019 | 0.73 | IDO1 (0.57) | IDO1CSNK1A1TYRO3DYRK1BNPC1 | |
| SCHEMBL8558526 | 0.73 | NPC1 (0.40) | IDO1CSNK1A1TYRO3DYRK1BPIM1 | |
| SCHEMBL8539541 | 0.73 | CYP1A2 (0.43) | MC4RCASP6IDO1CSNK1A1TYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0857171-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-08-12 | — | — | EP | disclosed |
| WO-1997015555-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-05-01 | — | — | WO | disclosed |