Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8536429 | 0.90 | VCAM1 (0.50) | VCAM1MAPTCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL8541143 | 0.79 | MAPK1 (0.51) | MAPTMEN1KMT2ALMNAPDE4B | |
| SCHEMBL31658933 | 0.79 | S100A4 (0.44) | MEN1KMT2ACCNB2CDK1CCNB1 | |
| SCHEMBL8541098 | 0.79 | TDP1 (0.47) | MAPTMEN1KMT2ACCNB2CDK1 | |
| SCHEMBL8542469 | 0.79 | TSHR (0.49) | MAPTMEN1KMT2ALMNACCNB2 | |
| SCHEMBL10680334 | 0.76 | MAPT (0.39) | MAPTMEN1KMT2ALMNACCNB2 | |
| SCHEMBL8539165 | 0.76 | MAPT (0.40) | VCAM1MAPTMEN1KMT2APDE4A | |
| SCHEMBL31486076 | 0.76 | CYP19A1 (0.45) | CYP19A1CYP11B1CYP11B2HCRTR1HCRTR2 | |
| SCHEMBL1303527 | 0.75 | CSNK1A1 (0.50) | MAPTMEN1KMT2A | |
| SCHEMBL8536034 | 0.74 | ESR1 (0.43) | MAPTMEN1KMT2ACCNB2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0857171-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-08-12 | — | — | EP | disclosed |
| WO-1997015555-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-05-01 | — | — | WO | disclosed |