Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CMA1 | P23946 | 1/20 | 0.47 |
| ▸ | ACACB | O00763 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1445857 | 0.85 | GAA (0.57) | GAAPOLBCMA1ACACBSMN1; SMN2 | |
| SCHEMBL4509396 | 0.82 | ACACB (0.64) | GAACMA1ACACBSMN1; SMN2ALDH1A1 | |
| SCHEMBL3459387 | 0.79 | L3MBTL1 (0.64) | GAACMA1ACACBSMN1; SMN2ALDH1A1 | |
| SCHEMBL20303832 | 0.78 | L3MBTL1 (0.67) | GAACMA1ACACBALDH1A1HDAC1 | |
| SCHEMBL158547 | 0.77 | GAA (0.55) | GAAPOLBCMA1ACACBALDH1A1 | |
| SCHEMBL29135192 | 0.77 | HDAC1 (0.51) | GAAPOLBCMA1ACACBSMN1; SMN2 | |
| SCHEMBL29135191 | 0.77 | HDAC1 (0.51) | GAAPOLBCMA1ACACBSMN1; SMN2 | |
| SCHEMBL8365726 | 0.76 | GAA (0.50) | GAAPOLBCMA1SMN1; SMN2ALDH1A1 | |
| SCHEMBL11432095 | 0.75 | GAA (0.68) | GAAPOLBCMA1ACACBSMN1; SMN2 | |
| SCHEMBL22743960 | 0.74 | GAA (0.54) | GAACMA1SMN1; SMN2ALDH1A1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5770611-A | Indole derivatives as 5HT1 -like agonists | PFIZER INC. (US) | 1998-06-23 | — | — | US | disclosed |
| EP-0785933-B1 | INDOLE DERIVATIVES AS 5HT1-LIKE AGONISTS | PFIZER LTD (GB) | 1998-03-11 | — | — | EP | disclosed |
| EP-0785933-A1 | INDOLE DERIVATIVES AS 5HT1-LIKE AGONISTS | Pfizer Limited (GB) | 1997-07-30 | — | — | EP | disclosed |
| WO-1996011195-A1 | INDOLE DERIVATIVES AS 5HT1-LIKE AGONISTS | PFIZER LIMITED (GB) | 1996-04-18 | — | — | WO | disclosed |
| US-4833152-A | Anti-hypertensive agents | UNIVERSITY OF MIAMI (US) | 1989-05-23 | — | — | US | disclosed |
| US-4745124-A | THIO/ESTER PEPTIDES | UNIVERSITY OF MIAMI (US) | 1988-05-17 | — | — | US | disclosed |
| US-4734420-A | INHIBITORS OF ANGIOTENSIN CONVERTING ENZYME | UNIVERSITY OF MIAMI (US) | 1988-03-29 | — | — | US | disclosed |
| US-4692458-A | Anti-hypertensive agents | UNIVERSITY OF MIAMI (US) | 1987-09-08 | — | — | US | disclosed |
| US-4690936-A | AMINO ACIDS, THIOESTER LINKAGE; ANGIOTENSIN INHIBITORS | UNIVERSITY OF MIAMI (US) | 1987-09-01 | — | — | US | disclosed |
| EP-0036713-B1 | ANGIOTENSIN CONVERTING ENZYME INHIBITORS | UNIVERSITY OF MIAMI (US) | 1984-01-18 | — | — | EP | disclosed |
| US-4284780-A | Amino acid derivatives | E. R. SQUIBB & SONS, INC. (US) | 1981-08-18 | — | — | US | disclosed |
| US-4179434-A | Amino acid derivatives | E. R. SQUIBB & SONS, INC. (US) | 1979-12-18 | — | — | US | disclosed |
| US-4177277-A | INHIBITION OF ANGIOTENSIN-CONVERTING ENZYME | E. R. SQUIBB & SONS, INC. (US) | 1979-12-04 | — | — | US | disclosed |
| US-4165320-A | Amino acid derivatives | E. R. SQUIBB & SONS, INC. (US) | 1979-08-21 | — | — | US | disclosed |
| US-4156786-A | Amino acid derivatives | E. R. SQUIBB & SONS, INC. (US) | 1979-05-29 | — | — | US | disclosed |
| US-4154960-A | Amino acid derivatives | E. R. SQUIBB & SONS, INC. (US) | 1979-05-15 | — | — | US | disclosed |
| US-4154946-A | Amino mercapto substituted acylamino acids | E. R. SQUIBB & SONS, INC. (US) | 1979-05-15 | — | — | US | disclosed |
| US-4146611-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1979-03-27 | — | — | US | disclosed |
| US-4129571-A | Amino acid derivatives | E. R. SQUIBB & SONS, INC. (US) | 1978-12-12 | — | — | US | disclosed |
| US-4113715-A | Amino acid derivatives | E. R. SQUIBB & SONS, INC. (US) | 1978-09-12 | — | — | US | disclosed |