Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | ASPH | Q12797 | 1/20 | 0.34 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8544930 | 0.81 | ALDH1A1 (0.49) | CYP3A4ALDH1A1TSHRHSD17B10POLB | |
| SCHEMBL8545120 | 0.81 | ALDH1A1 (0.58) | CYP3A4ALDH1A1TSHRHSD17B10POLB | |
| SCHEMBL8545932 | 0.77 | KDM4E (0.50) | ALDH1A1TSHRPOLBEGFRKDM4E | |
| SCHEMBL30517039 | 0.77 | KDM4E (0.50) | ALDH1A1TSHRPOLBEGFRKDM4E | |
| SCHEMBL4288671 | 0.77 | CYP3A4 (0.68) | CYP3A4ALDH1A1TSHRHSD17B10POLB | |
| SCHEMBL8788034 | 0.77 | CYP3A4 (0.55) | CYP3A4ALDH1A1TSHRHSD17B10POLB | |
| SCHEMBL11757412 | 0.76 | CYP3A4 (0.58) | CYP3A4ALDH1A1TSHRHSD17B10LMNA | |
| SCHEMBL27266429 | 0.76 | CYP3A4 (0.58) | CYP3A4ALDH1A1TSHRHSD17B10POLB | |
| SCHEMBL8788585 | 0.76 | CYP3A4 (0.58) | CYP3A4ALDH1A1TSHRHSD17B10POLB | |
| SCHEMBL11767742 | 0.75 | CYP3A4 (0.56) | CYP3A4ALDH1A1TSHRHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0581500-B1 | Antibiotic carbapenem compounds | ZENECA LTD (GB) | 1998-09-09 | — | — | EP | disclosed |
| US-5441949-A | Carbapenem antibiotic compounds | ZENECA LIMITED (GB) | 1995-08-15 | — | — | US | disclosed |
| EP-0581500-A1 | Antibiotic carbapenem compounds | ZENECA LIMITED (GB) | 1994-02-02 | — | — | EP | disclosed |