Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.49 |
| ▸ | MEN1 | O00255 | 7/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 8/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 2/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | TDO2 | P48775 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8540697 | 0.81 | CYP3A4 (0.46) | ALDH1A1KMT2AKDM4ECYP3A4MAPT | |
| SCHEMBL8545328 | 0.81 | ALDH1A1 (0.58) | ALDH1A1MEN1KMT2AKDM4ECYP3A4 | |
| SCHEMBL11973794 | 0.80 | PSMD14 (0.61) | ALDH1A1MEN1KMT2AKDM4ETDP1 | |
| SCHEMBL6537863 | 0.79 | ALDH1A1 (0.55) | ALDH1A1MEN1KMT2AKDM4ETDP1 | |
| SCHEMBL29800720 | 0.79 | MEN1 (0.60) | ALDH1A1MEN1KMT2AKDM4ETDP1 | |
| SCHEMBL27214168 | 0.79 | MEN1 (0.60) | ALDH1A1MEN1KMT2AKDM4ETDP1 | |
| SCHEMBL7820257 | 0.77 | KDM4E (0.61) | ALDH1A1MEN1KMT2AKDM4ETDP1 | |
| SCHEMBL4288671 | 0.77 | CYP3A4 (0.68) | ALDH1A1MEN1KMT2ACYP3A4MAPT | |
| SCHEMBL8788034 | 0.77 | CYP3A4 (0.55) | ALDH1A1KDM4ECYP3A4MAPTSMN1; SMN2 | |
| SCHEMBL8788585 | 0.76 | CYP3A4 (0.58) | ALDH1A1MEN1KMT2ATDP1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0581500-B1 | Antibiotic carbapenem compounds | ZENECA LTD (GB) | 1998-09-09 | — | — | EP | disclosed |
| US-5441949-A | Carbapenem antibiotic compounds | ZENECA LIMITED (GB) | 1995-08-15 | — | — | US | disclosed |
| EP-0581500-A1 | Antibiotic carbapenem compounds | ZENECA LIMITED (GB) | 1994-02-02 | — | — | EP | disclosed |