SCHEMBL8540748

SCHEMBL8540748

COc1cc(NN)c(C)cc1[N+](=O)[O-]

nearest known ligand 0.52

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LMNA P02545 6/20 0.52
SMN1; SMN2 Q16637 3/20 0.52
ALDH1A1 P00352 6/20 0.51
GAA P10253 1/20 0.49
KMT2A Q03164 7/20 0.46
KDM4E B2RXH2 1/20 0.46
MEN1 O00255 3/20 0.46
MAPT P10636 2/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
S1PR4 O95977 1/20 0.45
OPRK1 P41145 1/20 0.45
HTT P42858 1/20 0.45
RAB9A P51151 1/20 0.45
PAX8 Q06710 1/20 0.45
GPR55 Q9Y2T6 1/20 0.45
PTBP1 P26599 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL517401 0.81 HTT (0.50) LMNASMN1; SMN2ALDH1A1GAAKDM4E
SCHEMBL29785411 0.81 HTT (0.50) LMNASMN1; SMN2ALDH1A1GAAKDM4E
SCHEMBL636598 0.81 ALDH1A1 (0.53) LMNAALDH1A1KMT2AKDM4EMEN1
SCHEMBL14980793 0.81 LMNA (0.50) LMNASMN1; SMN2ALDH1A1GAAKMT2A
SCHEMBL8089043 0.81 ALDH1A1 (0.52) LMNASMN1; SMN2ALDH1A1GAAKDM4E
SCHEMBL359182 0.80 LMNA (0.61) LMNASMN1; SMN2ALDH1A1GAAKMT2A
SCHEMBL6370714 0.79 ALDH1A1 (0.50) LMNASMN1; SMN2ALDH1A1GAAKDM4E
SCHEMBL10778338 0.76 ALDH1A1 (0.62) LMNAALDH1A1KDM4EMAPTL3MBTL1
SCHEMBL11555366 0.75 HTT (0.55) LMNAALDH1A1GAAKMT2AKDM4E
SCHEMBL29738113 0.75 ALDH1A1 (0.50) LMNASMN1; SMN2ALDH1A1KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0797789-B1 NOVEL DIHYDRAZIDES AS DOT-PROMOTING AGENTS IN PHOTOGRAPHIC IMAGE SYSTEMS INT PAPER CO (US) 1998-11-25 EP disclosed