Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 3/20 | 0.45 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CCND3 | P30281 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | ADK | P55263 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | SI | P14410 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31429641 | 1.00 | GUSB (0.45) | GUSBAMY1ACSNK1A1TYRO3DYRK1B | |
| SCHEMBL8537911 | 0.90 | AMY1A (0.45) | GUSBAMY1ACSNK1A1TYRO3DYRK1B | |
| SCHEMBL28654223 | 0.86 | NISCH (0.50) | CSNK1A1TYRO3DYRK1BCDK4CCNA2 | |
| SCHEMBL14764328 | 0.85 | IDO1 (0.51) | CSNK1A1TYRO3DYRK1BNISCHMTOR | |
| SCHEMBL31429688 | 0.84 | CSNK1A1 (0.44) | AMY1ACSNK1A1TYRO3DYRK1BCDK4 | |
| SCHEMBL31429733 | 0.81 | IDO1 (0.58) | GUSBCSNK1A1TYRO3DYRK1BNISCH | |
| SCHEMBL31429646 | 0.81 | CASP6 (0.54) | AMY1ANPC1CASP6 | |
| SCHEMBL12088041 | 0.81 | NISCH (0.55) | CSNK1A1TYRO3DYRK1BNISCHMTOR | |
| SCHEMBL29084865 | 0.81 | IDO1 (0.58) | GUSBCSNK1A1TYRO3DYRK1BNISCH | |
| SCHEMBL1484995 | 0.81 | CASP6 (0.54) | AMY1ANPC1CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0857171-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-08-12 | — | — | EP | disclosed |
| WO-1997015555-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-05-01 | — | — | WO | disclosed |