SCHEMBL8541968

SCHEMBL8541968

NCc1cc(OC2CCNCC2)nc(C(F)(F)F)c1

nearest known ligand 0.54

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
LOXL2 Q9Y4K0 19/20 0.54
LOX P28300 6/20 0.48
IKBKB O14920 1/20 0.40
CHUK O15111 1/20 0.40
LCK P06239 1/20 0.40
ROCK1 Q13464 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27316040 0.90 LOXL2 (0.45) LOXL2LOXIKBKBCHUKLCK
SCHEMBL15390231 0.87 LOXL2 (0.44) LOXL2LOXROCK1
SCHEMBL30771875 0.85 LOXL2 (0.43) LOXL2LOX
SCHEMBL6121329 0.85 LOXL2 (0.43) LOXL2LOX
SCHEMBL15390719 0.85 LOXL2 (0.43) LOXL2LOX
SCHEMBL8545951 0.84 LOXL2 (0.42) LOXL2LOX
SCHEMBL8543452 0.83 LOXL2 (0.44) LOXL2LOX
SCHEMBL8579703 0.83 LOXL2 (0.44) LOXL2LOX
SCHEMBL22622482 0.82 LOXL2 (0.60) LOXL2LOX
SCHEMBL8577429 0.82 LOXL2 (0.41) LOXL2LOXROCK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022150676-A1 COMBINATION THERAPY COMPRISING JAK PATHWAY INHIBITOR AND ROCK INHIBITOR INCYTE CORPORATION (US) 2022-07-14 WO disclosed
WO-2022125670-A1 JAK1 PATHWAY INHIBITORS FOR THE TREATMENT OF VITILIGO INCYTE CORPORATION (US) 2022-06-16 WO disclosed
WO-2021076124-A1 USE OF JAK1 INHIBITORS FOR THE TREATMENT OF CUTANEOUS LUPUS ERYTHEMATOSUS AND LICHEN PLANUS (LP) INCYTE CORPORATION (US) 2021-04-22 WO disclosed
WO-2021072098-A1 BIOMARKERS FOR GRAFT-VERSUS-HOST DISEASE INCYTE CORPORATION (US) 2021-04-15 WO disclosed
EP-3795152-A1 TREATMENT OF B-CELL MALIGNANCIES BY A COMBINATION JAK AND PI3K INHIBITOR Incyte Corporation (US) 2021-03-24 EP disclosed
EP-3129021-B1 TREATMENT OF B-CELL MALIGNANCIES BY A COMBINATION JAK AND PI3K INHIBITOR INCYTE CORP (US) 2020-09-23 EP disclosed
WO-2019191679-A1 BIOMARKERS FOR INFLAMMATORY SKIN DISEASE INCYTE CORPORATION (US) 2019-10-03 WO disclosed
WO-2019161098-A1 JAK1 PATHWAY INHIBITORS FOR THE TREATMENT OF CYTOKINE-RELATED DISORDERS INCYTE CORPORATION (US) 2019-08-22 WO disclosed
WO-2017035366-A1 PYRROLOPYRIMIDINE DERIVATIVES AS TAM INHIBITORS INCYTE CORPORATION (US) 2017-03-02 WO disclosed
WO-2012068450-A1 CYCLOBUTYL SUBSTITUTED PYRROLOPYRIDINE AND PYRROLOPYRIMIDINE DERIVATIVES AS JAK INHIBITORS INCYTE CORPORATION (US) 2012-05-24 WO disclosed