Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 10/20 | 0.41 |
| ▸ | SYK | P43405 | 3/20 | 0.40 |
| ▸ | LOX | P28300 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547706 | 0.89 | LOXL2 (0.41) | LOXL2SYKLOXTIPARPPIM1 | |
| SCHEMBL8545951 | 0.88 | LOXL2 (0.42) | LOXL2SYKLOXSLC6A4TIPARP | |
| SCHEMBL8544620 | 0.86 | LOXL2 (0.41) | LOXL2SYKLOXSLC6A4TIPARP | |
| SCHEMBL6121329 | 0.82 | LOXL2 (0.43) | LOXL2SYKLOXSLC6A4TIPARP | |
| SCHEMBL18522661 | 0.82 | LOXL2 (0.42) | LOXL2SYKLOXPIM1PIM3 | |
| SCHEMBL15390231 | 0.82 | LOXL2 (0.44) | LOXL2SYKLOXSLC6A4TIPARP | |
| SCHEMBL8541968 | 0.82 | LOXL2 (0.54) | LOXL2LOXROCK1 | |
| SCHEMBL16532794 | 0.81 | AXL (0.46) | LOXL2SYKLOXPIM1PIM3 | |
| SCHEMBL16532797 | 0.81 | AXL (0.46) | LOXL2SYKLOXPIM1PIM3 | |
| SCHEMBL16532796 | 0.81 | LOXL2 (0.40) | LOXL2SYKLOXSLC6A4PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068450-A1 | CYCLOBUTYL SUBSTITUTED PYRROLOPYRIDINE AND PYRROLOPYRIMIDINE DERIVATIVES AS JAK INHIBITORS | INCYTE CORPORATION (US) | 2012-05-24 | — | — | WO | disclosed |