Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 12/20 | 0.43 |
| ▸ | CTSS | P25774 | 2/20 | 0.43 |
| ▸ | APLNR | P35414 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA7 | P43166 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27468579 | 0.87 | CTSK (0.46) | CTSKCTSSAPLNRGAAMEN1 | |
| SCHEMBL28735209 | 0.85 | APLNR (0.45) | CTSKCTSSAPLNRCA1CA7 | |
| SCHEMBL25268587 | 0.83 | APLNR (0.41) | CTSKCTSSAPLNRCA1CA7 | |
| SCHEMBL2681437 | 0.82 | CTSK (0.43) | CTSKCTSSAPLNRCA1CA7 | |
| SCHEMBL2681435 | 0.82 | CTSK (0.43) | CTSKCTSSAPLNRCA1CA7 | |
| SCHEMBL13636358 | 0.81 | CTSK (0.53) | CTSKCTSSCA1CA7CA2 | |
| SCHEMBL8494819 | 0.81 | APLNR (0.45) | CTSKCTSSAPLNRCA1CA7 | |
| SCHEMBL14274530 | 0.81 | CTSK (0.53) | CTSKCTSSCA1CA7CA2 | |
| SCHEMBL6380162 | 0.81 | APLNR (0.45) | CTSKCTSSAPLNRCA1CA7 | |
| SCHEMBL17980908 | 0.81 | CTSK (0.53) | CTSKCTSSCA1CA7CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101939313-B | 3,8-diaminotetrahydroquinoline derivative | ZERIA PHARM CO LTD | 2013-05-22 | — | — | CN | disclosed |
| CN-101939313-A | 3,8-diamino tetrahydroquinoline derivative | ZERIA PHARM CO LTD | 2011-01-05 | — | — | CN | disclosed |
| US-5837705-A | AN ANTAGONIST OF EXCITATORY AMINO ACID AND GLYCINE RECEPTOR FOR TREATING NEURODEGENERATIVE DISORDER, STROKE, HYPOGLYCEMIA, ISCHEMIC ATTACK, ANOXIA OR EPILEPSY | ZENECA LIMITED (GB) | 1998-11-17 | — | — | US | disclosed |