Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | CCR6 | P51684 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | FBP1 | P09467 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8543768 | 1.00 | MAPT (0.70) | MAPTKDM4EALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL9364793 | 0.87 | KDM4E (0.67) | MAPTKDM4EALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL9364797 | 0.87 | KDM4E (0.67) | MAPTKDM4EALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL17397040 | 0.87 | KDM4E (0.67) | MAPTKDM4EALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL17397039 | 0.87 | KDM4E (0.67) | MAPTKDM4EALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL21457626 | 0.83 | ALDH1A1 (0.76) | MAPTKDM4EALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL21457622 | 0.83 | ALDH1A1 (0.76) | MAPTKDM4EALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL11448492 | 0.82 | MAPT (1.00) | MAPTKDM4EALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL29894113 | 0.81 | CYP1A2 (0.63) | MAPTKDM4EALDH1A1KMT2ALMNA | |
| SCHEMBL4943479 | 0.81 | CYP1A2 (0.63) | MAPTKDM4EALDH1A1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0537949-B1 | Antiproliferative derivatives of 4H-naphtho 1,2-b pyran | LILLY CO ELI (GB) | 1998-07-01 | — | — | EP | disclosed |
| US-5284868-A | Naphthopyran derivatives; for autoimmune diseases, cancer | ELI LILLY AND COMPANY (US) | 1994-02-08 | — | — | US | disclosed |
| US-5281619-A | Administering naphtho(1,2-B)pyran derivatives | ELI LILLY AND COMPANY (US) | 1994-01-25 | — | — | US | disclosed |
| EP-0537949-A1 | Antiproliferative derivatives of 4H-naphtho 1,2-b pyran | LILLY INDUSTRIES LIMITED (GB) | 1993-04-21 | — | — | EP | disclosed |