SCHEMBL8544162

SCHEMBL8544162

CC(C)(C)C(=O)CC1N=C(c2cnccn2)c2ccccc2N(N)C1=O

nearest known ligand 0.50

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CCKBR P32239 3/20 0.39
CCKAR P32238 1/20 0.39
HDAC3 O15379 4/20 0.36
HDAC1 Q13547 3/20 0.36
HDAC6 Q9UBN7 3/20 0.36
HDAC8 Q9BY41 1/20 0.36
SCN9A Q15858 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8550576 0.81 HDAC3 (0.39) CCKBRCCKARHDAC3HDAC1HDAC6
SCHEMBL8541650 0.80 HDAC3 (0.36) CCKBRCCKARHDAC3HDAC1HDAC6
SCHEMBL8545456 0.79 SENP1 (0.42) CCKBRCCKARHDAC3HDAC1HDAC6
SCHEMBL8606324 0.78 CCKBR (0.50) CCKBRCCKAR
SCHEMBL8544165 0.78 CCKBR (0.50) CCKBRCCKAR
SCHEMBL8548821 0.71 CYP1A2 (0.48) CCKBRCCKARHDAC3HDAC1HDAC6
SCHEMBL8606948 0.69 SENP1 (0.57) CCKBRCCKAR
SCHEMBL8545459 0.69 SENP1 (0.57) CCKBRCCKAR
SCHEMBL1387729 0.67 CCKAR (0.76) CCKBRCCKAR
SCHEMBL1387730 0.67 CCKAR (0.76) CCKBRCCKAR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0715624-B1 PROCESS FOR THE PREPARATION OF BENZODIAZEPINE COMPOUNDS USEFUL AS ANTAGONISTS OF CCK OR OF GASTRINE YAMANOUCHI PHARMA CO LTD (JP) 1998-04-08 EP disclosed
US-5728829-A MULTISTAGE REACTION OF N-PROTECTED BENZOTRIAZOLYL GLYCINE DERIVATIVE WITH AMINOKETONE, THEN REACTION WITH AMMONIA AND ACID CATALYZED CYCLIZATION FERRING-RESEARCH LIMITED (GB) 1998-03-17 US disclosed
WO-1995006040-A1 BENZODIAZEPINE COMPOUNDS USEFUL AS ANTAGONISTS OF CCK OR OF GASTRINE YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1995-03-02 WO disclosed