Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 4/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | ICMT | O60725 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.32 |
| ▸ | GPX4 | P36969 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8543076 | 0.96 | BCHE (0.66) | BCHESLC6A2ACHEICMTKDM4C | |
| SCHEMBL8543972 | 0.86 | SLC6A2 (0.57) | BCHESLC6A2 | |
| SCHEMBL8546109 | 0.84 | BCHE (0.48) | BCHESLC6A2ICMTKDM4CNPC1 | |
| SCHEMBL8544810 | 0.82 | SLC6A2 (0.59) | BCHESLC6A2 | |
| SCHEMBL7609605 | 0.80 | BCHE (0.68) | BCHESLC6A2ACHEICMT | |
| SCHEMBL8544197 | 0.80 | BCHE (0.49) | BCHESLC6A2KDM4C | |
| Hydrochloric Acid SCHEMBL8543732 | 0.80 | BCHE (0.49) | BCHESLC6A2KDM4C | |
| SCHEMBL8544657 | 0.80 | BCHE (0.72) | BCHESLC6A2ACHEKDM4C | |
| SCHEMBL8537919 | 0.79 | BCHE (0.94) | BCHEACHE | |
| SCHEMBL8544182 | 0.79 | BCHE (0.67) | BCHESLC6A2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0468401-B1 | 1-(Substituted pyridinylamino)-1H-indol-5-yl substituted carbamates, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1998-09-16 | — | — | EP | disclosed |
| EP-0468401-A2 | 1-(Substituted pyridinylamino)-1H-indol-5-yl substituted carbamates, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-01-29 | — | — | EP | disclosed |