Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 6/20 | 0.57 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.51 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8544411 | 0.92 | GPBAR1 (0.61) | CYSLTR1GPBAR1ALOX5FFAR1AKR1B1 | |
| SCHEMBL8545793 | 0.90 | CYSLTR1 (0.54) | CYSLTR1CYSLTR2GPBAR1ALOX5FFAR1 | |
| SCHEMBL8539216 | 0.82 | GPBAR1 (0.57) | CYSLTR1CYSLTR2GPBAR1ALOX5FFAR1 | |
| SCHEMBL9828760 | 0.80 | CYSLTR1 (0.74) | CYSLTR1CYSLTR2GPBAR1ALOX5FFAR1 | |
| SCHEMBL912699 | 0.79 | IDH1 (0.45) | — | |
| SCHEMBL8542225 | 0.79 | GPBAR1 (0.39) | CYSLTR1CYSLTR2GPBAR1ALOX5FFAR1 | |
| SCHEMBL3271439 | 0.79 | CYSLTR1 (0.76) | CYSLTR1CYSLTR2GPBAR1ALOX5FFAR1 | |
| SCHEMBL8543705 | 0.79 | CYSLTR1 (0.61) | CYSLTR1CYSLTR2GPBAR1ALOX5FFAR1 | |
| SCHEMBL8540638 | 0.78 | ALOX5 (0.50) | CYSLTR1CYSLTR2GPBAR1ALOX5FFAR1 | |
| SCHEMBL26771304 | 0.76 | CYSLTR1 (0.65) | CYSLTR1CYSLTR2GPBAR1ALOX5FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539117-B1 | Compounds useful as leukotriene antagonists | LILLY CO ELI (GB) | 1998-03-11 | — | — | EP | disclosed |
| US-5410061-A | Leukotriene antagonist | LILLY INDUSTRIES LIMITED (GB) | 1995-04-25 | — | — | US | disclosed |
| EP-0539117-A1 | Compounds useful as leukotriene antagonists | LILLY INDUSTRIES LIMITED (GB) | 1993-04-28 | — | — | EP | disclosed |