Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8544257 | 1.00 | HSD11B1 (0.46) | HSD11B1EPHX1P2RX7FAAHALDH1A1 | |
| SCHEMBL8549484 | 0.89 | KMT2A (0.47) | HSD11B1EPHX1ALDH1A1KDM4EHTT | |
| SCHEMBL8549491 | 0.89 | KMT2A (0.47) | HSD11B1EPHX1ALDH1A1KDM4EHTT | |
| SCHEMBL8549977 | 0.89 | HSD11B1 (0.44) | HSD11B1EPHX1P2RX7FAAHALDH1A1 | |
| SCHEMBL8549703 | 0.87 | CNR2 (0.47) | HSD11B1P2RX7ALDH1A1HTTMAPT | |
| SCHEMBL8549691 | 0.87 | CNR2 (0.47) | HSD11B1P2RX7ALDH1A1HTTMAPT | |
| SCHEMBL8546685 | 0.85 | HSD11B1 (0.54) | HSD11B1EPHX1FAAHALDH1A1NPSR1 | |
| SCHEMBL8546679 | 0.85 | HSD11B1 (0.54) | HSD11B1EPHX1FAAHALDH1A1NPSR1 | |
| SCHEMBL8813502 | 0.85 | HSD11B1 (0.41) | HSD11B1EPHX1P2RX7FAAHNPSR1 | |
| SCHEMBL8543192 | 0.85 | HSD11B1 (0.54) | HSD11B1EPHX1P2RX7ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0564924-B1 | 2-Oxoethyl derivatives as immunosuppressants | BAYER AG (US) | 1998-09-09 | — | — | EP | claimed |
| US-5686424-A | FOR TREATING INFLAMMATION | MILES INC. (US) | 1997-11-11 | — | — | US | claimed |
| EP-0564924-A2 | 2-Oxoethyl derivatives as immunosuppressants | Bayer Corporation (US) | 1993-10-13 | — | — | EP | claimed |
| EP-0564924-B1 | 2-Oxoethyl derivatives as immunosuppressants | BAYER AG (US) | 1998-09-09 | — | — | EP | disclosed |
| US-5686424-A | FOR TREATING INFLAMMATION | MILES INC. (US) | 1997-11-11 | — | — | US | disclosed |
| EP-0564924-A2 | 2-Oxoethyl derivatives as immunosuppressants | Bayer Corporation (US) | 1993-10-13 | — | — | EP | disclosed |