Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 8/20 | 0.48 |
| ▸ | RAB9A | P51151 | 7/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | EDNRA | P25101 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7801729 | 1.00 | KMT2A (0.57) | KMT2AALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7800904 | 0.90 | NPC1 (0.50) | KMT2AALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL795101 | 0.90 | MAOB (0.50) | KMT2AALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7802114 | 0.89 | KMT2A (0.55) | KMT2AALDH1A1NPC1RAB9AEDNRA | |
| SCHEMBL8547479 | 0.85 | NPC1 (0.47) | KMT2AALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7799665 | 0.85 | NPC1 (0.47) | KMT2AALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7791690 | 0.84 | ALDH1A1 (0.50) | KMT2AALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7791683 | 0.84 | RAB9A (0.47) | KMT2AALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7791782 | 0.83 | ALDH1A1 (0.41) | KMT2AALDH1A1NPC1RAB9ATDP1 | |
| SCHEMBL7791788 | 0.82 | KMT2A (0.43) | KMT2AALDH1A1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876364-A2 | SUBSTITUTED PHENYL COMPOUNDS AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997025321-A2 | SUBSTITUTED PHENYL COMPOUNDS AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1997-07-17 | — | — | WO | disclosed |