Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2B | Q02880 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | ECE1 | P42892 | 1/20 | 0.36 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | TERT | O14746 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8542449 | 0.86 | TOP2B (0.49) | TOP2BMEN1POLBBLMKMT2A | |
| Hydrochloric Acid SCHEMBL8545200 | 0.84 | TOP2B (0.48) | TOP2BMEN1POLBBLMKMT2A | |
| SCHEMBL8547413 | 0.83 | MEN1 (0.44) | TOP2BMEN1POLBBLMKMT2A | |
| SCHEMBL8542305 | 0.82 | TERT (0.45) | TOP2BMEN1POLBBLMKMT2A | |
| SCHEMBL8544036 | 0.79 | TOP2B (0.54) | TOP2BMEN1POLBBLMKMT2A | |
| SCHEMBL8540388 | 0.79 | ECE1 (0.45) | TOP2BMEN1POLBBLMKMT2A | |
| SCHEMBL9197459 | 0.78 | ECE1 (0.42) | TOP2BMEN1POLBBLMKMT2A | |
| SCHEMBL8544126 | 0.77 | CYP19A1 (0.54) | TOP2BMEN1POLBBLMKMT2A | |
| SCHEMBL8539070 | 0.77 | TOP2B (0.42) | TOP2BMEN1POLBBLMKMT2A | |
| SCHEMBL8544765 | 0.77 | KMT2A (0.41) | TOP2BMEN1POLBBLMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0639183-B1 | NITROGEN OXIDES OF AZA- AND DIAZA-ANTHRACENEDIONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | BOEHRINGER MANNHEIM ITALIA (IT) | 1998-07-01 | — | — | EP | disclosed |