Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD5 | P21918 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8544809 | 1.00 | DRD1 (0.43) | DRD1DRD2DRD4DRD5DRD3 | |
| SCHEMBL8544812 | 1.00 | DRD1 (0.43) | DRD1DRD2DRD4DRD5DRD3 | |
| SCHEMBL8967434 | 0.84 | SIGMAR1 (0.44) | DRD2DRD4DRD3 | |
| SCHEMBL8544500 | 0.84 | SIGMAR1 (0.44) | DRD2DRD4DRD3 | |
| SCHEMBL8544501 | 0.84 | SIGMAR1 (0.44) | DRD2DRD4DRD3 | |
| SCHEMBL8967406 | 0.83 | CHRNA7 (0.42) | SLC6A4SLC6A3SLC6A2MEN1KMT2A | |
| SCHEMBL8541939 | 0.83 | CHRNA7 (0.42) | SLC6A4SLC6A3SLC6A2MEN1KMT2A | |
| SCHEMBL8541943 | 0.83 | CHRNA7 (0.42) | SLC6A4SLC6A3SLC6A2MEN1KMT2A | |
| SCHEMBL8546489 | 0.83 | CHRNA7 (0.42) | SLC6A4SLC6A3SLC6A2MEN1KMT2A | |
| SCHEMBL8544085 | 0.82 | DRD2 (0.46) | DRD2HTR2CSLC6A4SLC6A3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690842-B1 | 4-ARYLISOINDOLE ANALGESICS | ORTHO PHARMA CORP (US) | 1998-12-16 | — | — | EP | disclosed |
| US-5508424-A | REDUCED SIDE EFFECTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1996-04-16 | — | — | US | disclosed |
| WO-1994022823-A1 | 4-ARYLISOINDOLE ANALGESICS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1994-10-13 | — | — | WO | disclosed |