Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.45 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21104542 | 0.83 | P4HTM (0.55) | P4HTMHSD17B10KAT6AKMT2AMEN1 | |
| SCHEMBL478979 | 0.82 | KDM4E (0.53) | ALDH1A1KDM4CKDM4EHSD17B10SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8306980 | 0.81 | KDM4E (0.51) | ALDH1A1KDM4CKDM4EP4HTMHSD17B10 | |
| SCHEMBL17806411 | 0.80 | SMN1; SMN2 (0.51) | ALDH1A1KDM4CKDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL15831223 | 0.80 | P4HTM (0.58) | ALDH1A1KDM4EP4HTMHSD17B10SMN1; SMN2 | |
| SCHEMBL8432857 | 0.80 | POLB (0.47) | P4HTMSMN1; SMN2NPSR1NPC1POLB | |
| SCHEMBL9302340 | 0.79 | KDM4E (0.57) | ALDH1A1KDM4CKDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL8543957 | 0.78 | ALDH1A1 (0.49) | ALDH1A1KDM4CKDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL3650360 | 0.77 | NPSR1 (0.59) | ALDH1A1KDM4CKDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL8548910 | 0.77 | KMT2A (0.57) | ALDH1A1SMN1; SMN2LMNANPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0508796-B1 | Cholecystokinin antagonists | MERCK & CO INC (US) | 1998-07-08 | — | — | EP | disclosed |
| US-5597818-A | CARDIOVASCULAR DISORDERS | MERCK & CO., INC. (US) | 1997-01-28 | — | — | US | disclosed |
| US-5428031-A | Benzodiazepine analogs; cardiovascular disorders | MERCK & CO., INC. (US) | 1995-06-27 | — | — | US | disclosed |
| US-5360802-A | Antagonists of cholecystokinin and gastrin | MERCK SHARPE & DOHME LTD. | 1994-11-01 | — | — | US | disclosed |
| US-5302591-A | Nervous system disorders | MERCK SHARPE & DOHME LTD. (GB) | 1994-04-12 | — | — | US | disclosed |
| US-5220018-A | Benzodiazepine derivatives | MERCK & CO., INC. (US) | 1993-06-15 | — | — | US | disclosed |
| EP-0514133-A1 | Benzodiazepine derivatives, compositions containing them and their use in therapy | MERCK SHARP & DOHME LTD. (GB) | 1992-11-19 | — | — | EP | disclosed |
| EP-0508796-A1 | Cholecystokinin antagonists | MERCK & CO. INC. (US) | 1992-10-14 | — | — | EP | disclosed |