Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 3/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
| ▸ | FNTA | P49354 | 2/20 | 0.40 |
| ▸ | FNTB | P49356 | 2/20 | 0.40 |
| ▸ | RORC | P51449 | 6/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.38 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.37 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.37 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.37 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.37 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.37 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.37 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.37 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.37 |
| ▸ | CACNG1 | Q06432 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9248237 | 0.84 | TACR1 (0.68) | TACR1ALKFNTAFNTBRORC | |
| SCHEMBL7885109 | 0.84 | TACR1 (0.68) | TACR1ALKFNTAFNTBRORC | |
| SCHEMBL8546697 | 0.84 | TACR1 (0.68) | TACR1ALKFNTAFNTBRORC | |
| SCHEMBL8956775 | 0.83 | TACR1 (0.54) | TACR1ALKFNTAFNTBRORC | |
| SCHEMBL8548123 | 0.82 | TACR1 (0.73) | TACR1FNTAFNTBGRIN2BMEN1 | |
| SCHEMBL9141321 | 0.82 | TACR1 (0.73) | TACR1FNTAFNTBGRIN2BMEN1 | |
| SCHEMBL8894433 | 0.82 | TACR1 (0.73) | TACR1FNTAFNTBGRIN2BMEN1 | |
| SCHEMBL9142783 | 0.82 | FNTA (0.60) | TACR1FNTAFNTBGRIN2BMEN1 | |
| SCHEMBL8783447 | 0.79 | FNTA (0.53) | TACR1FNTAFNTBGRIN2BMEN1 | |
| SCHEMBL8894771 | 0.79 | FNTA (0.46) | TACR1FNTAFNTBGRIN2BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0635002-B1 | NOVEL PERHYDROISOINDOLE DERIVATIVES AND PREPARATION THEREOF | RHONE POULENC RORER SA (FR) | 1998-07-22 | — | — | EP | claimed |
| US-5631279-A | ANTAGONISTS OF NEUROKININ A | RHONE-POULENC RORER, S.A. (FR) | 1997-05-20 | — | — | US | disclosed |
| US-5484804-A | Perhydroisoindole derivatives as antagonists of substance P | RHONE-POULENC RORER S.A. (FR) | 1996-01-16 | — | — | US | disclosed |
| US-5463077-A | Exhibit substance P antagonist activity | RHONE-POULENC RORER S.A. (FR) | 1995-10-31 | — | — | US | disclosed |