Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 15/20 | 0.51 |
| ▸ | EDNRA | P25101 | 15/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8546008 | 0.91 | EDNRB (0.60) | EDNRBEDNRA | |
| SCHEMBL8545376 | 0.91 | EDNRB (0.59) | EDNRBEDNRA | |
| SCHEMBL8543272 | 0.86 | EDNRB (0.60) | EDNRBEDNRA | |
| SCHEMBL8856544 | 0.86 | EDNRB (0.60) | EDNRBEDNRA | |
| SCHEMBL8546889 | 0.84 | LMNA (0.51) | EDNRBEDNRALMNAMAPTHPGD | |
| SCHEMBL8592047 | 0.80 | EDNRB (0.59) | EDNRBEDNRA | |
| SCHEMBL8546146 | 0.80 | EDNRB (0.58) | EDNRBEDNRA | |
| SCHEMBL8616220 | 0.78 | MAPT (0.51) | EDNRBEDNRALMNAMAPTHPGD | |
| SCHEMBL8856577 | 0.78 | EDNRB (0.64) | EDNRBEDNRA | |
| SCHEMBL8856873 | 0.77 | EDNRA (0.65) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0800389-A4 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 1998-04-29 | — | — | EP | disclosed |
| US-5684032-A | ANTIINFLAMMATORY AGENTS, ANTIARTHRITIC, ANTIASTHMATIC AGENTS AND RESPIRATORY DISORDERS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-11-04 | — | — | US | disclosed |
| EP-0800389-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-10-15 | — | — | EP | disclosed |
| WO-1996018393-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-06-20 | — | — | WO | disclosed |