Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | MMP1 | P03956 | 1/20 | 0.55 |
| ▸ | MMP2 | P08253 | 1/20 | 0.55 |
| ▸ | MMP9 | P14780 | 1/20 | 0.55 |
| ▸ | MMP8 | P22894 | 1/20 | 0.55 |
| ▸ | MMP13 | P45452 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | ALB | P02768 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6279910 | 0.88 | EGFR (0.56) | EGFRERBB2LMNACA1CA2 | |
| SCHEMBL28405273 | 0.85 | EGFR (0.60) | EGFRERBB2LMNACA1CA2 | |
| SCHEMBL7969578 | 0.85 | EGFR (0.60) | EGFRERBB2LMNACA1CA2 | |
| SCHEMBL692083 | 0.84 | LMNA (0.64) | LMNACA1CA2MMP1MMP2 | |
| SCHEMBL13537908 | 0.84 | CA1 (0.68) | EGFRERBB2LMNACA1CA2 | |
| SCHEMBL2635660 | 0.84 | EGFR (0.63) | EGFRERBB2LMNACA1CA2 | |
| SCHEMBL5931139 | 0.84 | ALDH1A1 (0.71) | EGFRERBB2LMNACA1CA2 | |
| SCHEMBL5177119 | 0.83 | EGFR (0.55) | EGFRERBB2LMNACA1CA2 | |
| SCHEMBL13800951 | 0.82 | EGFR (0.51) | EGFRERBB2LMNAALDH1A1KMT2A | |
| Ammonia Solution, Strong SCHEMBL6098128 | 0.82 | LMNA (0.62) | LMNACA1CA2MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0580633-B1 | HETEROCYCLIC AMINES USEFUL IN THE THERAPY OF ASTHMA AND INFLAMMATION OF THE RESPIRATORY TRACT | BOEHRINGER MANNHEIM ITALIA (IT) | 1998-06-17 | — | — | EP | disclosed |
| US-5453423-A | Heterocyclic amines useful in the therapy of asthma and imflammation of the respiratory tract | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1995-09-26 | — | — | US | disclosed |
| EP-0580633-A1 | HETEROCYCLIC AMINES USEFUL IN THE THERAPY OF ASTHMA AND INFLAMMATION OF THE RESPIRATORY TRACT | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1994-02-02 | — | — | EP | disclosed |
| WO-1992018478-A1 | HETEROCYCLIC AMINES USEFUL IN THE THERAPY OF ASTHMA AND INFLAMMATION OF THE RESPIRATORY TRACT | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-10-29 | — | — | WO | disclosed |