Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 10/20 | 0.69 |
| ▸ | EDNRA | P25101 | 9/20 | 0.69 |
| ▸ | SERPINE1 | P05121 | 5/20 | 0.54 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.48 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8856902 | 0.91 | EDNRB (0.58) | EDNRBEDNRASERPINE1S1PR5MAPK8 | |
| SCHEMBL4711435 | 0.84 | MAPK8 (0.66) | EDNRBEDNRAMAPK8 | |
| SCHEMBL8540948 | 0.83 | EDNRA (0.72) | EDNRBEDNRAS1PR5 | |
| SCHEMBL6858271 | 0.81 | EDNRB (0.55) | EDNRBEDNRAPLA2G2A | |
| SCHEMBL8551430 | 0.81 | EDNRB (0.80) | EDNRBEDNRASERPINE1PLA2G2A | |
| SCHEMBL8643680 | 0.81 | EDNRA (0.78) | EDNRBEDNRA | |
| SCHEMBL6858334 | 0.80 | EDNRB (0.62) | EDNRBEDNRASERPINE1PLA2G2A | |
| SCHEMBL8856638 | 0.80 | EDNRA (0.78) | EDNRBEDNRA | |
| SCHEMBL8857076 | 0.80 | EDNRB (0.64) | EDNRBEDNRA | |
| SCHEMBL8856815 | 0.79 | EDNRB (0.74) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0800389-A4 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 1998-04-29 | — | — | EP | claimed |
| EP-0800389-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-10-15 | — | — | EP | claimed |
| WO-1996018393-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-06-20 | — | — | WO | claimed |
| US-5684032-A | ANTIINFLAMMATORY AGENTS, ANTIARTHRITIC, ANTIASTHMATIC AGENTS AND RESPIRATORY DISORDERS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-11-04 | — | — | US | disclosed |