Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 4/20 | 0.58 |
| ▸ | EDNRA | P25101 | 4/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.49 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.49 |
| ▸ | SERPINE1 | P05121 | 4/20 | 0.48 |
| ▸ | CCR2 | P41597 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8545345 | 0.91 | EDNRB (0.69) | EDNRBEDNRAS1PR5SERPINE1MAPK8 | |
| SCHEMBL2808240 | 0.84 | SERPINE1 (0.57) | EDNRBEDNRAHDAC6SERPINE1NR4A1 | |
| SCHEMBL5419800 | 0.80 | SERPINE1 (0.66) | EDNRBEDNRAHDAC6HDAC1FOLH1 | |
| SCHEMBL4711435 | 0.80 | MAPK8 (0.66) | EDNRBEDNRAMAPK8 | |
| SCHEMBL8643680 | 0.79 | EDNRA (0.78) | EDNRBEDNRA | |
| SCHEMBL8857009 | 0.78 | MCL1 (0.58) | EDNRBEDNRATP53FOLH1 | |
| SCHEMBL27361848 | 0.77 | EDNRB (0.54) | EDNRBEDNRAHDAC6HDAC1FOLH1 | |
| SCHEMBL5426724 | 0.77 | EDNRB (0.52) | EDNRBEDNRAHDAC6HDAC1FOLH1 | |
| SCHEMBL19133588 | 0.76 | EDNRB (0.59) | EDNRBEDNRAHDAC6HDAC1FOLH1 | |
| SCHEMBL9023540 | 0.76 | EDNRB (0.54) | EDNRBEDNRATP53SERPINE1CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684032-A | ANTIINFLAMMATORY AGENTS, ANTIARTHRITIC, ANTIASTHMATIC AGENTS AND RESPIRATORY DISORDERS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-11-04 | — | — | US | disclosed |