Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 3/20 | 0.65 |
| ▸ | CYP19A1 | P11511 | 11/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.50 |
| ▸ | NQO2 | P16083 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | SNCA | P37840 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | PKLR | P30613 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11387455 | 0.79 | TBXAS1 (1.00) | TBXAS1CYP19A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL11349273 | 0.79 | TBXAS1 (0.72) | TBXAS1CYP19A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL11493719 | 0.79 | TBXAS1 (0.72) | TBXAS1CYP19A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL11488802 | 0.79 | TBXAS1 (0.72) | TBXAS1CYP19A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL11494396 | 0.79 | TBXAS1 (0.72) | TBXAS1CYP19A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8580515 | 0.77 | CYP19A1 (0.53) | TBXAS1CYP19A1KMT2AMEN1CYP11B1 | |
| SCHEMBL29106569 | 0.76 | CYP19A1 (0.62) | CYP19A1KMT2ACYP11B1CYP11B2CDK1 | |
| SCHEMBL6998678 | 0.76 | CYP19A1 (0.66) | CYP19A1KMT2ACYP11B1CYP11B2CDK1 | |
| SCHEMBL14473096 | 0.76 | CYP19A1 (0.62) | CYP19A1KMT2ACYP11B1CYP11B2CDK1 | |
| SCHEMBL27929617 | 0.76 | NQO2 (0.61) | KMT2AMEN1SMN1; SMN2NQO2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0715627-B1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | PFIZER LTD (GB) | 1998-09-09 | — | — | EP | disclosed |
| US-5744488-A | 1-CARBOXYALKYL-3-ALKYL OR PHENYL-5-ORGANOSULFONAMIDE OR -AMIDE INDOLES; ATHERSCLEROSIS; ANGINA; PREVENTING ANGIOPLASTY OCCULSION; THROMBOXANE SYNTHETASE INHIBITORS | PFIZER INC. (US) | 1998-04-28 | — | — | US | disclosed |