SCHEMBL8545440

SCHEMBL8545440

CCCCOc1ccc2[nH]cc(CCN(C)C)c2c1Cl

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 9/20 0.55
HTR1D P28221 8/20 0.55
HTR1B P28222 6/20 0.55
HTR6 P50406 4/20 0.50
HTR2A P28223 8/20 0.47
SLC6A4 P31645 2/20 0.47
HTR2C P28335 6/20 0.46
HTR2B P41595 6/20 0.46
HTR1E P28566 2/20 0.46
HTR7 P34969 2/20 0.46
HTR5A P47898 2/20 0.46
DRD1 P21728 1/20 0.46
ADORA2A P29274 1/20 0.46
ADORA2B P29275 1/20 0.46
DRD3 P35462 1/20 0.46
HTR3E A5X5Y0 1/20 0.44
HTR3B O95264 1/20 0.44
CYP1A2 P05177 1/20 0.44
CYP2D6 P10635 1/20 0.44
CYP2C9 P11712 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8545081 0.94 HTR1A (0.55) HTR1AHTR1DHTR1BHTR6HTR2A
SCHEMBL8549767 0.88 HTR2A (0.44) HTR1AHTR1DHTR1BHTR6HTR2A
Fumaric Acid SCHEMBL8544768 0.85 HTR1A (0.51) HTR1AHTR1DHTR1BHTR6HTR2A
Fumaric Acid SCHEMBL8544764 0.85 HTR1A (0.51) HTR1AHTR1DHTR1BHTR6HTR2A
Fumaric Acid SCHEMBL30011017 0.85 HTR1A (0.51) HTR1AHTR1DHTR1BHTR6HTR2A
SCHEMBL8544351 0.84 HTR2A (0.45) HTR1AHTR1DHTR1BHTR6HTR2A
SCHEMBL8543450 0.83 HTR1A (0.71) HTR1AHTR1DHTR1BHTR6HTR2A
SCHEMBL9076548 0.83 HTR1A (0.54) HTR1AHTR1DHTR1BHTR6HTR2A
SCHEMBL12596305 0.82 HTR6 (0.70) HTR1AHTR1DHTR1BHTR6HTR2A
SCHEMBL8549160 0.81 HTR2A (0.45) HTR1AHTR1DHTR1BHTR6HTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0593513-B1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE RECEPTORS OR 5-HT2 RECEPTOR AGONISTES SMITHKLINE BEECHAM PLC (GB) 1998-10-28 EP claimed
US-5571833-A TREATMENT OF MIGRAINE, PORTAL HYPERTENSION SMITHKLINE BEECHAM PLC (GB) 1996-11-05 US claimed
EP-0593513-A1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE RECEPTORS OR 5-HT2 RECEPTOR AGONISTES SMITHKLINE BEECHAM PLC (GB) 1994-04-27 EP claimed
WO-1993000333-A1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE OR 5-HT2 RECEPTOR AGONISTS SMITHKLINE BEECHAM PLC (GB) 1993-01-07 WO claimed
EP-0593513-B1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE RECEPTORS OR 5-HT2 RECEPTOR AGONISTES SMITHKLINE BEECHAM PLC (GB) 1998-10-28 EP disclosed
US-5571833-A TREATMENT OF MIGRAINE, PORTAL HYPERTENSION SMITHKLINE BEECHAM PLC (GB) 1996-11-05 US disclosed
EP-0593513-A1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE RECEPTORS OR 5-HT2 RECEPTOR AGONISTES SMITHKLINE BEECHAM PLC (GB) 1994-04-27 EP disclosed
WO-1993000333-A1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE OR 5-HT2 RECEPTOR AGONISTS SMITHKLINE BEECHAM PLC (GB) 1993-01-07 WO disclosed