Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | GALR3 | O60755 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7342646 | 0.89 | KMT2A (0.54) | KMT2AALDH1A1SMN1; SMN2CYP3A4POLB | |
| SCHEMBL28327252 | 0.85 | KMT2A (0.59) | KMT2AALDH1A1SMN1; SMN2CYP3A4POLB | |
| SCHEMBL5182501 | 0.79 | KMT2A (0.59) | KMT2AALDH1A1SMN1; SMN2CYP3A4POLB | |
| SCHEMBL2813658 | 0.78 | HSD17B10 (0.51) | KMT2AALDH1A1SMN1; SMN2CYP3A4POLB | |
| SCHEMBL4440258 | 0.78 | HSD17B10 (0.51) | KMT2AALDH1A1SMN1; SMN2CYP3A4POLB | |
| SCHEMBL2817984 | 0.75 | HSD17B10 (0.51) | KMT2AALDH1A1SMN1; SMN2CYP3A4MEN1 | |
| SCHEMBL2816593 | 0.75 | HSD17B10 (0.51) | KMT2AALDH1A1SMN1; SMN2CYP3A4MEN1 | |
| SCHEMBL2815063 | 0.75 | ALDH1A1 (0.45) | KMT2AALDH1A1CYP3A4POLBTDP1 | |
| SCHEMBL6398309 | 0.74 | KMT2A (0.71) | KMT2AALDH1A1SMN1; SMN2CYP3A4POLB | |
| SCHEMBL28405139 | 0.74 | KMT2A (0.57) | KMT2AALDH1A1SMN1; SMN2CYP3A4POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0483881-B1 | 3-Amidoindolyl derivatives | MERRELL PHARMA INC (US) | 1998-01-21 | — | — | EP | disclosed |
| US-5675018-A | 3-amidoindolyl derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1997-10-07 | — | — | US | disclosed |
| US-5491153-A | 3-amidoindolyl derivative | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-02-13 | — | — | US | disclosed |
| US-5189054-A | 3-amidoindolyl derivatives and pharmaceutical compositions thereof | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-02-23 | — | — | US | disclosed |
| EP-0483881-A1 | 3-Amidoindolyl derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1992-05-06 | — | — | EP | disclosed |