Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.43 |
| ▸ | KDR | P35968 | 4/20 | 0.40 |
| ▸ | AURKA | O14965 | 3/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.40 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | LTK | P29376 | 1/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8365522 | 0.97 | EGFR (0.47) | EGFRERBB2KDRAURKAAURKB | |
| SCHEMBL8368308 | 0.94 | EGFR (0.49) | EGFRERBB2KDRAURKAAURKB | |
| SCHEMBL8541789 | 0.88 | EGFR (0.47) | EGFRERBB2KDRAURKAAURKB | |
| SCHEMBL8367919 | 0.87 | EGFR (0.54) | EGFRERBB2ERBB4JAK3 | |
| SCHEMBL8538985 | 0.86 | EGFR (0.47) | EGFRERBB2KDRAURKAAURKB | |
| SCHEMBL8363554 | 0.85 | EGFR (0.47) | EGFRERBB2KDRAURKAAURKB | |
| SCHEMBL8368186 | 0.85 | EGFR (0.52) | EGFRERBB2AURKAAURKBERBB4 | |
| SCHEMBL8363483 | 0.85 | EGFR (0.49) | EGFRERBB2KDRAURKAAURKB | |
| SCHEMBL8367388 | 0.85 | EGFR (0.53) | EGFRERBB2ERBB4JAK3SRC | |
| SCHEMBL8367320 | 0.85 | EGFR (0.54) | EGFRERBB2KDRAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999035132-A1 | HETEROCYCLIC COMPOUNDS | GLAXO GROUP LIMITED (GB) | 1999-07-15 | — | — | WO | disclosed |