Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4850384 | 0.91 | MAOB (0.42) | LMNAMAOBHSD11B1MAPTHTR3A | |
| SCHEMBL21156819 | 0.83 | LMNA (0.46) | LMNAMAOBHSD11B1MAPTHTR3A | |
| SCHEMBL4862180 | 0.80 | MAOB (0.44) | LMNAMAOBMAPTALDH1A1KDM4E | |
| SCHEMBL29670373 | 0.79 | ALDH1A1 (0.52) | LMNAHSD11B1MAPTALDH1A1TP53 | |
| SCHEMBL21156821 | 0.79 | LMNA (0.51) | LMNAMAOBHSD11B1MAPTHTR3A | |
| SCHEMBL1759317 | 0.79 | ALDH1A1 (0.52) | LMNAHSD11B1MAPTALDH1A1TP53 | |
| SCHEMBL25184324 | 0.78 | LMNA (0.50) | LMNAMAOBHSD11B1MAPTHTR3A | |
| SCHEMBL31473248 | 0.78 | KDM4E (0.57) | LMNAMAOBHSD11B1MAPTHTR3A | |
| Hydrochloric Acid SCHEMBL31473354 | 0.77 | KDM4E (0.55) | LMNAMAOBHSD11B1MAPTHTR3A | |
| SCHEMBL16548565 | 0.75 | POLB (0.48) | LMNAHSD11B1MAPTHTR3AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709384-B1 | Benzylpiperidine derivatives having high affinity for binding sites of aminoacid receptors | MERCK PATENT GMBH (DE) | 1998-12-23 | — | — | EP | disclosed |
| US-5698553-A | Benzylpiperidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-12-16 | — | — | US | disclosed |
| EP-0709384-A1 | Benzylpiperidine derivatives having high affinity for binding sites of aminoacid receptors | MERCK PATENT GmbH (DE) | 1996-05-01 | — | — | EP | disclosed |