Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 15/20 | 0.66 |
| ▸ | PTGS1 | P23219 | 10/20 | 0.66 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8148477 | 0.89 | PTGS2 (0.51) | PTGS2PTGS1MAOAMAOBCA12 | |
| SCHEMBL8552103 | 0.89 | PTGS2 (0.51) | PTGS2PTGS1MAOAMAOBCA12 | |
| SCHEMBL8547731 | 0.88 | PTGS2 (0.50) | PTGS2PTGS1CA12CA1CA2 | |
| SCHEMBL8552170 | 0.88 | PTGS2 (0.50) | PTGS2PTGS1MAOAMAOBCA12 | |
| SCHEMBL8547060 | 0.88 | PTGS2 (0.50) | PTGS2PTGS1MAOAMAOBCA12 | |
| SCHEMBL7503991 | 0.84 | PTGS2 (0.67) | PTGS2PTGS1MAOAMAOBCA2 | |
| SCHEMBL7501777 | 0.84 | PTGS2 (0.58) | PTGS2PTGS1MAOAMAOBCA12 | |
| SCHEMBL7508637 | 0.84 | PTGS2 (0.67) | PTGS2PTGS1MAOAMAOBCA12 | |
| SCHEMBL7502663 | 0.83 | PTGS2 (0.57) | PTGS2PTGS1MAOAMAOBCA12 | |
| SCHEMBL7500957 | 0.83 | PTGS2 (0.57) | PTGS2PTGS1MAOAMAOBCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825989-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-03-04 | — | — | EP | claimed |
| WO-1996036617-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-21 | — | — | WO | claimed |
| EP-0864570-A1 | Epoxy-azetidinones, preparation and use thereof | PLIVA farmaceutska, kemijska, prehrambena i kozmeticka industrija, dionicko drustvo (HR) | 1998-09-16 | — | — | EP | disclosed |
| EP-0825989-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-03-04 | — | — | EP | disclosed |
| WO-1996036617-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-21 | — | — | WO | disclosed |