Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.50 |
| ▸ | CA2 | P00918 | 11/20 | 0.47 |
| ▸ | CA9 | Q16790 | 9/20 | 0.47 |
| ▸ | CA12 | O43570 | 7/20 | 0.47 |
| ▸ | CA1 | P00915 | 8/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPY1R | P25929 | 1/20 | 0.43 |
| ▸ | NPY2R | P49146 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 2/20 | 0.41 |
| ▸ | CA4 | P22748 | 3/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8148477 | 0.89 | PTGS2 (0.51) | PTGS2PTGS1CA2CA9CA12 | |
| SCHEMBL8552103 | 0.89 | PTGS2 (0.51) | PTGS2PTGS1CA2CA9CA12 | |
| SCHEMBL8552170 | 0.88 | PTGS2 (0.50) | PTGS2PTGS1CA2CA9CA12 | |
| SCHEMBL8546102 | 0.88 | PTGS2 (0.66) | PTGS2PTGS1CA2CA9CA12 | |
| SCHEMBL8547060 | 0.88 | PTGS2 (0.50) | PTGS2PTGS1CA2CA9CA12 | |
| SCHEMBL8552080 | 0.81 | CA2 (0.52) | PTGS2PTGS1CA2CA9CA12 | |
| SCHEMBL8552563 | 0.81 | CA2 (0.52) | PTGS2PTGS1CA2CA9CA12 | |
| SCHEMBL8140711 | 0.80 | PTGS2 (0.76) | PTGS2PTGS1CA2CA9CA12 | |
| SCHEMBL8552366 | 0.80 | PTGS2 (0.76) | PTGS2PTGS1CA2CA9CA12 | |
| SCHEMBL7502659 | 0.76 | CA1 (0.56) | PTGS2PTGS1CA2CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825989-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-03-04 | — | — | EP | claimed |
| WO-1996036617-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-21 | — | — | WO | claimed |
| EP-0825989-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-03-04 | — | — | EP | disclosed |
| WO-1996036617-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-21 | — | — | WO | disclosed |