Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4205207 | 0.87 | TACR1 (0.44) | TSHRLMNAALDH1A1GAAATM | |
| SCHEMBL8533478 | 0.85 | LMNA (0.42) | TSHRSMN1; SMN2LMNAALDH1A1HSD17B10 | |
| SCHEMBL8531571 | 0.83 | TACR1 (0.45) | TSHRSMN1; SMN2LMNAALDH1A1HSD17B10 | |
| SCHEMBL4205532 | 0.79 | ATM (0.45) | TSHRSMN1; SMN2LMNAALDH1A1MAPT | |
| SCHEMBL8531579 | 0.78 | ALDH1A1 (0.51) | TSHRSMN1; SMN2LMNAALDH1A1HSD17B10 | |
| SCHEMBL8546062 | 0.77 | TACR1 (0.48) | TSHRLMNAALDH1A1GAAHPGD | |
| SCHEMBL8531284 | 0.76 | ALDH1A1 (0.59) | TSHRSMN1; SMN2LMNAALDH1A1HSD17B10 | |
| SCHEMBL8531896 | 0.76 | MAPT (0.49) | TSHRSMN1; SMN2LMNAALDH1A1MAPT | |
| SCHEMBL8529656 | 0.75 | TACR1 (0.46) | TSHRSMN1; SMN2LMNAALDH1A1HSD17B10 | |
| SCHEMBL310305 | 0.75 | TACR1 (0.44) | ALDH1A1MAPTHPGDATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0720609-B1 | 3-(5-TETRAZOLYL-BENZYL)AMINO-PIPERIDINE DERIVATIVES AND ANTAGONISTS OF TACHYKININS | GLAXO GROUP LTD (GB) | 1998-11-11 | — | — | EP | disclosed |
| EP-0720609-A1 | 3-(5-TETRAZOLYL-BENZYL)AMINO-PIPERIDINE DERIVATIVES AND ANTAGONISTS OF TACHYKININS | GLAXO GROUP LIMITED (GB) | 1996-07-10 | — | — | EP | disclosed |
| WO-1995008549-A1 | 3-(5-TETRAZOLYL-BENZYL)AMINO-PIPERIDINE DERIVATIVES AND ANTAGONISTS OF TACHYKININS | GLAXO GROUP LIMITED (GB) | 1995-03-30 | — | — | WO | disclosed |