Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8539622 | 0.99 | MAPT (0.35) | MAPTLOXL2KCNH3 | |
| SCHEMBL9739945 | 0.82 | ROCK1 (0.43) | — | |
| Hydrochloric Acid SCHEMBL8544421 | 0.81 | ROCK1 (0.43) | KCNH3 | |
| SCHEMBL8539192 | 0.81 | ORAI1 (0.33) | MAPT | |
| SCHEMBL8539327 | 0.81 | BCHE (0.49) | MAPT | |
| SCHEMBL7616001 | 0.80 | BCHE (0.44) | LOXL2SLC6A2 | |
| SCHEMBL8544202 | 0.79 | BCHE (0.36) | SLC6A2 | |
| Hydrochloric Acid SCHEMBL8543739 | 0.78 | BCHE (0.35) | SLC6A2 | |
| SCHEMBL9738844 | 0.78 | BCHE (0.51) | — | |
| Hydrochloric Acid SCHEMBL9671993 | 0.78 | BCHE (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0468401-B1 | 1-(Substituted pyridinylamino)-1H-indol-5-yl substituted carbamates, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1998-09-16 | — | — | EP | disclosed |
| US-5102891-A | Useful for treating various memory dysfunctions such as alzheimer's disease | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1992-04-07 | — | — | US | disclosed |
| EP-0468401-A2 | 1-(Substituted pyridinylamino)-1H-indol-5-yl substituted carbamates, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-01-29 | — | — | EP | disclosed |