Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 5/20 | 0.82 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.82 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.82 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.82 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.82 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.82 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.82 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1908150 | 0.90 | GRIN2B (1.00) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL7418720 | 0.87 | GRIN2B (0.74) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL7959501 | 0.86 | ENPP2 (0.74) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL7000889 | 0.84 | GRIN1 (0.60) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL108026 | 0.84 | GRIN2B (0.67) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL8546472 | 0.84 | GRIN1 (0.60) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL8547576 | 0.84 | GRIN2B (0.67) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL8109896 | 0.83 | GRIN1 (0.69) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL7528460 | 0.82 | GRIN2B (0.79) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL7418723 | 0.82 | GRIN1 (0.62) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709384-B1 | Benzylpiperidine derivatives having high affinity for binding sites of aminoacid receptors | MERCK PATENT GMBH (DE) | 1998-12-23 | — | — | EP | disclosed |
| EP-0709384-A1 | Benzylpiperidine derivatives having high affinity for binding sites of aminoacid receptors | MERCK PATENT GmbH (DE) | 1996-05-01 | — | — | EP | disclosed |